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Cholinergic neuromuscular hyperactivity in patients with myasthenia gravis seropositive for MuSK antibody
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Klinisk neurofysiologi. (Erik Stålberg)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Klinisk neurofysiologi. (Erik Stålberg)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Klinisk neurofysiologi. (Erik Stålberg)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Klinisk neurofysiologi. (Erik Stålberg)
2006 (engelsk)Inngår i: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 34, nr 1, s. 111-115Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A 75-year-old man with severe oculobulbar myasthenia gravis (MG) treated with acetylcholine esterase inhibitors (AChEIs) was found to have muscle-specific tyrosine kinase (MuSK) antibodies. Neurophysiological examination displayed extra repetitive discharges after the compound motor action potential (CMAP) at low-frequency stimulation, possibly triggered by AChEI. This indicates an abnormal sensitivity to acetylcholine in patients with MuSK antibodies and may be a useful indicator of the adverse effect of AChEI treatment in these patients. Muscle Nerve, 2006

sted, utgiver, år, opplag, sider
2006. Vol. 34, nr 1, s. 111-115
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-95261DOI: 10.1002/mus.20515PubMedID: 16453324OAI: oai:DiVA.org:uu-95261DiVA, id: diva2:169409
Tilgjengelig fra: 2006-12-15 Laget: 2006-12-15 Sist oppdatert: 2017-12-14bibliografisk kontrollert
Inngår i avhandling
1. MuSK Antibody(+) Versus AChR Antibody(+) Myasthenia Gravis: Clinical, Neurophysiological and Morphological Aspects
Åpne denne publikasjonen i ny fane eller vindu >>MuSK Antibody(+) Versus AChR Antibody(+) Myasthenia Gravis: Clinical, Neurophysiological and Morphological Aspects
2007 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Myasthenia gravis (MG) is an autoimmune neuromuscular disorder that causes fluctuating muscle weakness. MG may be divided into an ocular form and a generalized form based on the involved muscles. Treatment differs between these different MG forms. The majority (80%) of patients with generalized MG are seropositive for antibodies against the acetylcholine receptor (AChR-Ab). Recently a new antibody was detected against muscle specific tyrosine kinase (MuSK) in about 40% of patients who are AChR-Ab seronegative. A few patients with MuSK-Abs have muscular atrophies, as well as electrophysiological myopathy.

In this thesis we have characterized MuSK-Ab seropositive [MuSK(+)] patients using clinical parameters, including health-related quality of life (hrQoL), neurophysiology and muscle morphology, and compared them to patients with and without AChR-Abs. The question concerned which factors contribute to their muscle weakness. Additionally, we wanted to determine if single-fiber electromyography (SFEMG) in a limb muscle has any predictive value for generalization of ocular MG.

Our results suggest that MuSK(+) patients more often have a myopathic electromyography pattern, although this pattern is found also in other immunological subtypes of MG. The myopathic pattern may be associated with the frequently found mitochondrial abnormalities. However, disturbed neuromuscular transmission is the primary cause of muscle weakness in the majority of MuSK(+) patients, as well as in AChR-Ab seropositive patients. The disease-specific hrQoL MG questionnaire was successfully validated into Swedish and these scores correlated with disturbed neuromuscular transmission in a proximal arm muscle. Abnormal SFEMG findings occur also in muscles outside of the facial area in ocular MG, although this is not predictive of subsequent generalization.

MuSK (+) patients have little or no beneficial effect of acetylcholine esterase inhibitors (AChEI). On the contrary AChEI may produce profound adverse effects. We present the hypothesis that this effect of AChEI is due to abnormal receptor morphology in MuSK(+) patients.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2007. s. 73
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 211
Emneord
Neurosciences, myasthenia gravis, MuSK antibody, AChR antibody, myopathy, single-fiber EMG, mitochondria, Swedish MG questionnaire, quality of life, Neurovetenskap
Identifikatorer
urn:nbn:se:uu:diva-7408 (URN)91-554-6752-0 (ISBN)
Disputas
2007-02-02, Grönwallssalen, Akademiska sjukhuset, ingång 70, 75185 Uppsala, 13:15
Opponent
Veileder
Tilgjengelig fra: 2006-12-15 Laget: 2006-12-15bibliografisk kontrollert

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