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Synthesis of tetrahydroisoquinoline (TIQ)-oxazoline ligands and their application in enantioselective Henry reactions
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för biokemi och organisk kemi.
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2010 (engelsk)Inngår i: Tetrahedron: asymmetry, ISSN 0957-4166, E-ISSN 1362-511X, Vol. 21, nr 7, s. 846-852Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A novel family of eleven new tetrahydroisoquinoline (TIQ)-oxazoline intermediates and five corresponding copper(II) catalysts has been developed and applied to the catalytic asymmetric Henry reaction of various aldehydes with nitromethane to provide beta-hydroxy nitroalkanes in high conversion (>99%) This paper describes the synthesis of the TIQ compounds from L-dihydroxyphenylalanine (L-DOPA) as the starting material The chiral ligands were complexed in situ with various transition metals such as Cu, Sc, Co, Zn, Ni and Mn and tested as a chiral catalyst for the Henry reaction The reaction was optimized in terms of the metal, counter ion, solvent, temperature and over a range of substrates The corresponding catalyst with copper(II) acetate and 2-propanol as the solvent provides the best enantioselectivities (up to 77% ee) of the corresponding nitroalcohol for 4-chlorobenzaldehyde.

sted, utgiver, år, opplag, sider
2010. Vol. 21, nr 7, s. 846-852
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URN: urn:nbn:se:uu:diva-136005DOI: 10.1016/j.tetasy.2010.04.053ISI: 000279493400014OAI: oai:DiVA.org:uu-136005DiVA, id: diva2:376283
Tilgjengelig fra: 2010-12-10 Laget: 2010-12-09 Sist oppdatert: 2017-12-11bibliografisk kontrollert

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