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A Comparison of Different Definitions of Growth Response in Short Prepubertal Children Treated with Growth Hormone
Vise andre og tillknytning
2011 (engelsk)Inngår i: Hormone Research in Paediatrics, ISSN 1663-2818, Vol. 75, nr 5, s. 335-345Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: How to define poor growth response in the management of short growth hormone (GH)-treated children is controversial. Aim: Assess various criteria of poor response. Subjects and Methods: Short GH-treated prepubertal children [n = 456; height (Ht) SD score (SDS) <=-2] with idiopathic GH deficiency (IGHD, n = 173), idiopathic short stature (ISS, n = 37), small for gestational age (SGA, n = 54), organic GHD (OGHD, n = 40), Turner syndrome (TS, n = 43), skeletal dysplasia (n = 15), other diseases (n = 46) or syndromes (n = 48) were evaluated in this retrospective multicenter study. Median age at GH start was 6.3 years and Ht SDS -3.2. Results: Median [25-75 percentile] first-year gain in Ht SDS was 0.65 (0.40-0.90) and height velocity (HtV) 8.67 (7.51-9.90) cm/year. Almost 50% of IGHD children fulfilled at least one criterion for poor responders. In 28% of IGHD children, Ht SDS gain was <0.5 and they had lower increases in median IGF-I SDS than those with Ht SDS >0.5. Only IGHD patients with peak stimulated growth hormone level <3 mu g/l responded better than those with ISS. A higher proportion of children with TS, skeletal dysplasia or born SGA had Ht SDS gain <0.5. Conclusion: Many children respond poorly to GH therapy. Recommendations defining a criterion may help in managing short stature patients.

sted, utgiver, år, opplag, sider
2011. Vol. 75, nr 5, s. 335-345
Emneord [en]
Growth hormone therapy, Growth response, Height velocity, Growth hormone deficiency, Organic growth hormone deficiency, Small for gestational age, Idiopathic short stature, Turner syndrome, Skeletal dysplasia, Growth prediction
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Identifikatorer
URN: urn:nbn:se:uu:diva-153992DOI: 10.1159/000322878ISI: 000290094100004PubMedID: 21228552OAI: oai:DiVA.org:uu-153992DiVA, id: diva2:418510
Tilgjengelig fra: 2011-05-23 Laget: 2011-05-23bibliografisk kontrollert

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