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Detailed assessment of copy number alterations revealing homozygous deletions in 1p and 13q in mantle cell lymphoma
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för genetik och patologi.
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2007 (engelsk)Inngår i: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 31, nr 9, s. 1219-1230Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Mantle cell lymphoma (MCL) is characterized by over-expression of cyclin Dl as a result of the characteristic t(11;14)(q13;q32). However, this translocation alone has proven not to be sufficient for lymphomagenesis, suggesting the involvement of additional alterations. We have characterized 35 cases of MCL by array comparative genomic hybridization with an average resolution of 0.97Mb distributed over the complete human genome. The most common alterations were losses in 1p13.2–p31.1, 6q16.2–q27, 8p21.3, 9p13.2–p24.3, 9q13–q31.3, 11q14.3–q23.3, 13q14.13–q21.31, 13q33.1–q34, and 22q11.23–q13.33 and gains involving 3q21.2–q29, 7p12.1–p22.3, 8q24.13–q24.23, and 18q21.33–q22.3. Four homozygous deletions were identified in totally three patients; two overlapping at 1p32.3, and two adjacent at 13q32.3. The homozygous deletions at 1p32.3 cover the CDKN2C locus (coding for p18), while the region at 13q32.3 does not encompass any known tumor suppressor genes. A gain in 3q was significantly associated with shorter survival (P=0.047).

sted, utgiver, år, opplag, sider
2007. Vol. 31, nr 9, s. 1219-1230
Emneord [en]
array-CGH, MCL, homozygous deletion, p18, V-H gene usage
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-17474DOI: 10.1016/j.leukres.2006.10.022ISI: 000248013000009PubMedID: 17161458OAI: oai:DiVA.org:uu-17474DiVA, id: diva2:45245
Tilgjengelig fra: 2008-06-24 Laget: 2008-06-24 Sist oppdatert: 2017-12-08bibliografisk kontrollert

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