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External quality assessment of HbA(1c) for point of care testing
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. (Biokemisk struktur och funktion)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. (biologiska membran)
2006 (engelsk)Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 111, nr 2, s. 201-207Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objectives. To evaluate the long term total imprecision of HbA(1c) testing within the county of Uppsala in relation to the Swedish analytical goal of coefficient of variation (CV) < 3% for HbA(1c) and to study the cost of an external quality assurance program for point-of-care HbA(1c) The county uses Bayer DCA 2000 (TM) for point-of care HbA(1c) testing currently having 23 of these instruments.

Methods. Method imprecision was assessed by analysis of patient samples performed as split samples during a 3 year period (2002-2004) as part of the quality assurance program for point-of-care HbA(1c) testing. The samples were first analysed on a Bayer DCA 2000 (TM) and the samples were then sent to the centralised laboratory for reanalysis with an HPLC system (Variant II (TM), Biorad). The testing was performed approximately 8 times per year with each instrument.

Results. The median CV between the HPLC method and the point-of-care instruments for each unit was slightly higher than 3%.

Conclusion. The DCA 2000 (TM) systems have an acceptable imprecision and agreement with the central laboratory. The test results show acceptable agreements within the county regardless where the patient is tested. The cost of the external quality assurance program is calculated to be approximately SEK 1340 (Euro 150) per instrument.

sted, utgiver, år, opplag, sider
2006. Vol. 111, nr 2, s. 201-207
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Identifikatorer
URN: urn:nbn:se:uu:diva-21803ISI: 000239322000004PubMedID: 16961175OAI: oai:DiVA.org:uu-21803DiVA, id: diva2:49576
Tilgjengelig fra: 2007-01-04 Laget: 2007-01-04 Sist oppdatert: 2017-12-07bibliografisk kontrollert

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