uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Two Loci on Chromosome 5 Are Associated with Serum IgE Levels in Labrador Retrievers
Vise andre og tillknytning
2012 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, nr 6, s. e39176-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Crosslinking of immunoglobulin E antibodies (IgE) bound at the surface of mast cells and subsequent mediator release is considered the most important trigger for allergic reactions. Therefore, the genetic control of IgE levels is studied in the context of allergic diseases, such as asthma, atopic rhinitis, or atopic dermatitis (AD). We performed genome-wide association studies in 161 Labrador Retrievers with regard to total and allergen-specific immunoglobulin E (IgE) levels. We identified a genome-wide significant association on CFA 5 with the antigen-specific IgE responsiveness to Acarus siro. We detected a second genome-wide significant association with respect to the antigen-specific IgE responsiveness to Tyrophagus putrescentiae at a different locus on chromosome 5. A. siro and T. putrescentiae both belong to the family Acaridae and represent so-called storage or forage mites. These forage mites are discussed as major allergen sources in canine AD. No obvious candidate gene for the regulation of IgE levels is located under the two association signals. Therefore our studies offer a chance of identifying a novel mechanism controlling the host's IgE response.

sted, utgiver, år, opplag, sider
2012. Vol. 7, nr 6, s. e39176-
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-176991DOI: 10.1371/journal.pone.0039176ISI: 000305350000046PubMedID: 22720065OAI: oai:DiVA.org:uu-176991DiVA, id: diva2:538475
Tilgjengelig fra: 2012-06-29 Laget: 2012-06-29 Sist oppdatert: 2017-12-07bibliografisk kontrollert

Open Access i DiVA

fulltext(432 kB)396 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 432 kBChecksum SHA-512
d2b66f97f790758a8d1c20035c92a16308c7ea2c879ea2c5bc27e95d6852993cf2ec26b749ae2fb9542385975617c81e5a8ad5ddfc4f057bd5de898d83560117
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Tengvall, KatarinaWebster, Matthew T.Lindblad-Toh, Kerstin

Søk i DiVA

Av forfatter/redaktør
Tengvall, KatarinaWebster, Matthew T.Lindblad-Toh, Kerstin
Av organisasjonen
I samme tidsskrift
PLoS ONE

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 396 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 809 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf