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Metabolism-dependent activation and toxicity of chemicals in nasal glands
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap. (Toxicology)
1997 (engelsk)Inngår i: Mutation research, ISSN 0027-5107, E-ISSN 1873-135X, Vol. 380, nr 1-2, s. 61-75Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The mucosae of the nasal passages contain a large amount of glands which express secretory proteins as well as phase I and phase II biotransformation enzymes. In this review the metabolic activation, covalent binding and toxicity of chemicals in the Bowman's glands in the olfactory mucosa, in the sere-mucous glands in the nasal septum and in the lateral nasal glands and maxillary glands around the maxillary sinuses are discussed. Light microscopic autoradiographic studies have demonstrated a selective covalent binding of nasal toxicants and carcinogens such as halogenated hydrocarbons and N-nitrosamines, especially in the Bowman's glands following a single systemic exposure, suggesting a high rate of metabolic activation of chemicals in these glands. Special attention is put on the herbicide dichlobenil which induces necrosis in the olfactory mucosa following a cytochrome-P450-mediated metabolic activation and covalent binding in the Bowman's glands.

sted, utgiver, år, opplag, sider
1997. Vol. 380, nr 1-2, s. 61-75
Emneord [en]
Bowman's gland, sero-mucous gland, lateral nasal gland, maxillary gland, olfactory mucosa, nasal mucosa, nasal toxicity, nasal P450, dichlobenil
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Identifikatorer
URN: urn:nbn:se:uu:diva-50764DOI: 10.1016/S0027-5107(97)00127-9ISI: A1997YE98400008PubMedID: 9385390OAI: oai:DiVA.org:uu-50764DiVA, id: diva2:78673
Tilgjengelig fra: 2005-05-26 Laget: 2005-05-26 Sist oppdatert: 2018-01-11bibliografisk kontrollert

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