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Splenic marginal-zone lymphoma: ontogeny and genetics
Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
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2015 (engelsk)Inngår i: Leukemia and Lymphoma, ISSN 1042-8194, E-ISSN 1029-2403, Vol. 56, nr 2, s. 301-310Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Splenic marginal-zone lymphoma (SMZL) is a rare tumor that has recently emerged as a prototype for how the interplay between genetics and environment shapes the natural history of lymphomas. Indeed, the recent identification of molecular immunogenetic subgroups within SMZL may prove to be relevant not only for the sub-classification of the disease but also for improved understanding of the underlying biology. In contrast to other B-cell lymphomas, SMZL lacks a characteristic genetic lesion, although the majority of cases harbor genomic aberrations, as recently revealed by high-throughput studies that identified recurrent genetic aberrations, several in pathways related to marginal-zone differentiation and B-cell signaling. Here we provide an overview of recent research into the molecular and cellular biology of SMZL and related disorders, with special emphasis on immunogenetics and genomic aberrations, and discuss the value of molecular and cellular markers for the diagnosis and differential diagnosis of these entities.

sted, utgiver, år, opplag, sider
2015. Vol. 56, nr 2, s. 301-310
Emneord [en]
Lymphoma and Hodgkin disease, cytogenetics, molecular genetics
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-247834DOI: 10.3109/10428194.2014.919636ISI: 000349662000008PubMedID: 24798744OAI: oai:DiVA.org:uu-247834DiVA, id: diva2:799180
Tilgjengelig fra: 2015-03-30 Laget: 2015-03-24 Sist oppdatert: 2017-12-04bibliografisk kontrollert

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