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X-ray microanalysis of in situ and isolated pancreatic islets
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk cellbiologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk cellbiologi.
Vise andre og tillknytning
1998 (engelsk)Inngår i: Pancreas, ISSN 0885-3177, E-ISSN 1536-4828, Vol. 16, nr 2, s. 134-140Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The effect of stimulation of insulin secretion in pancreatic beta cells on the elemental composition ofthese cells was investigated by x-ray microanalysis. In vitro experiments on isolated islets ofLangerhans from ob/ob mice were compared to in situ experiments. The only significant difference inthe elemental composition of beta cells from ob/ob mice versus their lean counterparts is a lower Ca concentration in the ob/ob animals. The nucleus of the beta cells has a higher concentration of P, K, and Na than the cytoplasm, which has a higher concentration of S and Cl. No polarized ion distributionin the cytoplasm of the beta cells was observed. Isolated beta cells show a higher concentration of Na and Cl and a lower concentration of K than their in situ counterparts. Stimulation of insulin secretion with glucose both in situ and in vitro showed only very small effects on the elemental composition of the beta cells: a tendency to a decreased P content was noted. In vitro experiments using stimulation with high extracellular K+ showed, in addition, a small increase in the intracellular K concentration. Inconclusion, while the elemental content of beta cells in vitro differs from that in situ, the response to glucose stimulation appears to be similar in both systems.

sted, utgiver, år, opplag, sider
1998. Vol. 16, nr 2, s. 134-140
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URN: urn:nbn:se:uu:diva-53154ISI: 000072267200005OAI: oai:DiVA.org:uu-53154DiVA, id: diva2:81064
Tilgjengelig fra: 2008-10-17 Laget: 2008-10-17 Sist oppdatert: 2017-12-04bibliografisk kontrollert

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