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Chimerism analysis in clinical practice and its relevance for the detection of graft rejection and malignant relapse in pediatric hematopoietic stem cell transplant patients
Univ Gothenburg, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden..
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
Skane Univ Hosp, Dept Pediat, Sect Pediat Oncol Hematol, Lund, Sweden..
Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
2015 (engelsk)Inngår i: Pediatric Transplantation, ISSN 1397-3142, E-ISSN 1399-3046, Vol. 19, nr 7, s. 758-766Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Chimerism and clinical outcome data from 244 hematopoietic stem cell transplants in 218 children were retrospectively analyzed to assess their relevance for the detection of graft rejection and malignant relapse. Patients transplanted for a non-malignant disease had significantly higher proportions of residual recipient T cells in peripheral blood at one, three, and sixmonths compared with patients transplanted for malignant disease. Recipient T-cell levels were below 50% at onemonth after transplantation in most patients (129 of 152 transplants). Graft rejection occurred more frequently in the group of patients with high levels of recipient cells at onemonth (10 graft rejections in the 23 patients with recipient T cells >50% at onemonth as compared to seven graft rejections occurred in 129 patients with recipient T cells <50% (p<0.001). Multilineage chimerism data in 87 children with leukemia at one, three, and sixmonths after transplantation were not correlated with subsequent relapse of malignant disease. In conclusion, early analysis of lineage-specific chimerism in peripheral blood can be used to identify patients who are at high risk of graft rejection. However, the efficacy of early chimerism analysis for predicting leukemia relapse was limited.

sted, utgiver, år, opplag, sider
2015. Vol. 19, nr 7, s. 758-766
Emneord [en]
chimerism analysis, stem cell transplantation, pediatric patients
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-265805DOI: 10.1111/petr.12580ISI: 000362580100022PubMedID: 26290161OAI: oai:DiVA.org:uu-265805DiVA, id: diva2:866709
Forskningsfinansiär
Swedish Childhood Cancer FoundationTilgjengelig fra: 2015-11-03 Laget: 2015-11-03 Sist oppdatert: 2017-12-01bibliografisk kontrollert

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