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Lithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis
Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan..
Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan..
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
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2015 (engelsk)Inngår i: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 48, nr 2, s. 403-410Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Background: This is the first meta-analysis of randomized placebo-controlled trials testing lithium as a treatment for patients with Alzheimer's disease (AD) and individuals with mild cognitive impairment (MCI). Methods: The primary outcome measure was efficacy on cognitive performance as measured through the Alzheimer's Disease Assessment Scale cognitive subscale or the Mini-Mental State Examination. Other outcome measures were drug discontinuation rate, individual side effects, and biological markers (phosphorylated tau 181, total tau, and amyloid-beta(42)) in cerebrospinal fluid (CSF). Results: Three clinical trials including 232 participants that met the study's inclusion criteria were identified. Lithium significantly decreased cognitive decline as compared to placebo (standardized mean difference = -0.41, 95% confidence interval = -0.81 to -0.02, p = 0.04, I-2 = 47%, 3 studies, n = 199). There were no significant differences in the rate of attrition, discontinuation due to all causes or adverse events, or CSF biomarkers between treatment groups. Conclusions: The results indicate that lithium treatment may have beneficial effects on cognitive performance in subjects with MCI and AD dementia.

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2015. Vol. 48, nr 2, s. 403-410
Emneord [en]
Alzheimer's disease, lithium, meta-analysis, mild cognitive impairment, systematic review
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Identifikatorer
URN: urn:nbn:se:uu:diva-265967DOI: 10.3233/JAD-150437ISI: 000361066200009PubMedID: 26402004OAI: oai:DiVA.org:uu-265967DiVA, id: diva2:867164
Tilgjengelig fra: 2015-11-04 Laget: 2015-11-04 Sist oppdatert: 2018-01-10bibliografisk kontrollert

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