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Preparation of imidazopyridinecarboxamide derivatives for use as GSK3 modulators.
2008 (engelsk)Patent (Annet (populærvitenskap, debatt, mm))
Resurstyp
Text
Abstract [en]

Title compds. I [Q = halo; R1 = CH2NR3R4; each R2 independently = H or alkyl; R3 and R4 = together with the atoms to which they are attached form an (un)substituted heterocyclic ring contg. one or more heteroatoms selected from N, O, or S; R6 = H or alkyl; R7 = H, (un)substituted alkyl, alkylaryl, aryl, or heteroaryl], and their pharmaceutically acceptable salts, are prepd. and disclosed as glycogen synthase kinase-3 (GSK3) modulators. Thus, e.g., II•HCl was prepd. by cyclocondensation of 5-bromopyridine-2,3-diamine with terephthalic monomethyl ester followed by chlorination, iodination, sapon., amidation with morpholine, redn., and coupling with carbon monoxide and 3-methoxy-1-propanamine. I were evaluated in GSK3β scintillation proximity assays, e.g., II•HCl demonstrated an Ki value of 390 nM. [on SciFinder(R)]

sted, utgiver, år, opplag, sider
AstraZeneca AB, Swed. . , 2008. nr WO2008121063A1
Emneord [en]
imidazopyridinecarboxamide deriv prepn GSK3 modulator
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-270233OAI: oai:DiVA.org:uu-270233DiVA, id: diva2:888181
Merknad

CAPLUS AN 2008:1210930(Patent)

Tilgjengelig fra: 2015-12-22 Laget: 2015-12-22 Sist oppdatert: 2018-01-10

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Yngve, Ulrika.

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