uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Evaluation of the protein biomarkers and the analgesic response to systemic methylene blue in patients with refractory neuropathic pain: a double blind, controlled study
Multidisciplinary Pain Clinic, Uppsala University Hospital, Sweden.
Multidisciplinary Pain Clinic, Uppsala University Hospital, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
2015 (engelsk)Inngår i: Journal of Pain Research, ISSN 1178-7090, E-ISSN 1178-7090, Vol. 8, s. 387-397Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Aim:

This study was carried out in patients with neuropathic pain in order to assess the analgesic effects and changes in protein biomarkers after the administration of methylene blue (MB), a diaminophenothiazine with antioxidant and anti-inflammatory properties, and with inhibitory effects on nitric oxide.

Materials and methods:

Ten patients with chronic refractory neuropathic pain were randomized to receive either MB (10 mg/mL Methylthioninium chloride) 2 mg/kg (MB group) or MB 0.02 mg/kg (control group) infused over 60 minutes. Sensory function and pain (Numerical Rating Scale) were evaluated at baseline and at 60 minutes after the start of the infusion. The patients kept a pain diary during the next 24 hours and for the following 4 days. Plasma and urinary concentrations of 8-isoprostane-prostaglandin F2α (8-iso-PGF2α) and plasma protein biomarkers prior to and after the infusions were measured with radioimmunoassay and with proximity extension assay.

Results:

A decrease of the Numerical Rating Scale at 60 minutes in comparison with baseline was observed in the MB (P=0.047) group. The decrease was significant between the MB and the control group on the day of and day after MB infusion (P=0.04 and P=0.008, respectively). There was no difference in systemic protein expressions between groups except for prolactin (PRL) (P=0.02). Three patients demonstrated diminished dynamic mechanical allodynia.

Conclusion:

MB decreased the pain levels in patients with chronic therapy-resistant neuropathic pain on the first 2 days after administration. Known as an endocrine modulator on the anterior pituitary gland, MB infusion produced a decrease of PRL. The detailed role of PRL effects in chronic neuropathic pain remains undetermined.

sted, utgiver, år, opplag, sider
2015. Vol. 8, s. 387-397
HSV kategori
Forskningsprogram
Anestesiologi och intensivvård
Identifikatorer
URN: urn:nbn:se:uu:diva-280189DOI: 10.2147/JPR.S84685OAI: oai:DiVA.org:uu-280189DiVA, id: diva2:910312
Tilgjengelig fra: 2016-03-08 Laget: 2016-03-08 Sist oppdatert: 2017-11-30bibliografisk kontrollert

Open Access i DiVA

fulltext(1902 kB)160 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1902 kBChecksum SHA-512
d708fe8b4890d013d9836d44498c5aeb44aa0faf9739ad091bd7a628ab289d8e545428042c041e161729d1a9a81dfdd2275bdf00e9f0eb89857d716644d069df
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekst

Personposter BETA

Miclescu, AdrianaGordh, Torsten

Søk i DiVA

Av forfatter/redaktør
Miclescu, AdrianaGordh, Torsten
Av organisasjonen
I samme tidsskrift
Journal of Pain Research

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 160 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 409 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf