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Computational inference of scenarios for alpha-proteobacterial genome evolution
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Teknisk-naturvetenskapliga fakulteten, Institutionen för evolution, genomik och systematik, Molekylär evolution.
2004 Ingår i: Proceedings of the national academy of sciences USA, ISSN 1091-6490, Vol. 101, nr 26, s. 9722-9727Artikel i tidskrift (Refereegranskat) Published
Ort, förlag, år, upplaga, sidor
2004. Vol. 101, nr 26, s. 9722-9727
Identifikatorer
URN: urn:nbn:se:uu:diva-93417OAI: oai:DiVA.org:uu-93417DiVA, id: diva2:166883
Tillgänglig från: 2005-09-09 Skapad: 2005-09-09Bibliografiskt granskad
Ingår i avhandling
1. Lifestyle and Genome Evolution in Vector-Borne Bacteria: A Comparison of Three Bartonella Species
Öppna denna publikation i ny flik eller fönster >>Lifestyle and Genome Evolution in Vector-Borne Bacteria: A Comparison of Three Bartonella Species
2005 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Alternativ titel[sv]
Livsstil och genomevolution i vektorburna bakterier : en jämförelse av tre Bartonella-arter
Abstract [en]

Bacterial genomes provide records of the molecular processes associated with emergence and evolution of different bacterial lifestyles. This thesis is based on whole-genome comparisons within the genus Bartonella, an excellent model system for studies of host- and vector-specificity and infection outcome in animal-associated bacteria. The louse-borne human specialist and trench fever agent Bartonella quintana was contrasted to the flea-borne generalist relatives Bartonella henselae and Bartonella grahamii, which cause asymptomatic infection in cat and mouse respectively. While B. henselae is commonly isolated from humans, and causes cat scratch disease, there is only one reported case of B. grahamii human infection.

The gene complements of the three species are nested like Russian dolls with the smaller genome (B. quintana) being entirely contained in the medium sized (B. henselae), which in turned is contained in the largest (B. grahamii). Size differences reflect differences in the horizontally and vertically acquired gene content, and in the number of genus- and species- specific genes, owing to differential impact of bacteriophages and plasmids, and to different degrees of genome decay. These processes can be attributed to the three distinct lifestyles.

Comparisons with other alpha-proteobacteria suggest that the Bartonella genus as a whole evolved from plant-associated species, and that horizontal transfer, in particular of genes involved in interaction with the host, played a key role in the transition to animal intracellular lifestyle. The long-term genome decay associated with this lifestyle is most advanced in the host-restricted B. quintana. The broad host-range species B. grahamii has the largest genome and the largest proportion of auxiliary DNA of the three, probably because it has access to a larger gene pool. In encodes all the known pathogenicity determinants found in the genomes of B. henselae and B. quintana, suggesting that these genes primarily evolved to facilitate colonization in the reservoir host.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2005. s. 57
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 87
Nyckelord
Biology, Bartonella, evolution, host-restriction, vector-borne, horizontal gene transfer, genome reduction, alpha-proteobacteria, Type-IV secretion, Biologi
Nationell ämneskategori
Biologiska vetenskaper
Identifikatorer
urn:nbn:se:uu:diva-5913 (URN)91-554-6326-6 (ISBN)
Disputation
2005-09-30, Zootissalen, Evolutionsbiologiskt centrum, Villavägen 9, Uppsala, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2005-09-09 Skapad: 2005-09-09 Senast uppdaterad: 2009-08-04Bibliografiskt granskad

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