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Association between shift work history and performance on the trail making test in middle-aged and elderly humans: the EpiHealth study
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.ORCID-id: 0000-0002-8552-4510
Lund Univ, Skane Univ Hosp, Sweden CRC, Dept Hlth Sci,Div Geriatr Med, Malmö, Sweden..
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.ORCID-id: 0000-0003-2335-8542
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2016 (Engelska)Ingår i: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 45, s. 23-29Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Shift work has been proposed to promote cognitive disturbances in humans; however, conflicting evidence is also present. By using data from 7143 middle-aged and elderly humans (45-75 years) who participated in the Swedish EpiHealth cohort study, the present analysis sought to investigate whether self-reported shift work history would be associated with performance on the trail making test (TMT). The TMT has been proposed to be a useful neuropsychological tool to evaluate humans' executive cognitive function, which is known to decrease with age. After adjustment for potential confounders (e.g., age, education, and sleep duration), it was observed that current and recent former shift workers (worked shifts during the past 5 years) performed worse on the TMT than nonshift workers. In contrast, performance on the TMT did not differ between past shift workers (off from shift work for more than 5 years) and nonshift workers. Collectively, our results indicate that shift work history is linked to poorer performance on the TMT in a cohort of middle-aged and elderly humans.

Ort, förlag, år, upplaga, sidor
2016. Vol. 45, s. 23-29
Nyckelord [en]
Shift work history, Trail making test, Cohort study
Nationell ämneskategori
Neurologi
Identifikatorer
URN: urn:nbn:se:uu:diva-303263DOI: 10.1016/j.neurobiolaging.2016.05.007ISI: 000381092900003PubMedID: 27459922OAI: oai:DiVA.org:uu-303263DiVA, id: diva2:1032924
Forskningsfinansiär
VetenskapsrådetHjärnfondenNovo NordiskTillgänglig från: 2016-10-05 Skapad: 2016-09-15 Senast uppdaterad: 2023-09-05Bibliografiskt granskad
Ingår i avhandling
1. Metabolic Health and Cognitive Function: The Roles of Lifestyle and Shift Work
Öppna denna publikation i ny flik eller fönster >>Metabolic Health and Cognitive Function: The Roles of Lifestyle and Shift Work
2019 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The risk of cognitive impairment and metabolic disturbances increases during aging. Healthy lifestyle habits, such as a regular intake of fatty fish and adherence to the Mediterranean diet (MeDi), have been shown to slow age-related cognitive decline and decrease the risk of metabolic disturbances. Conversely, poor lifestyle habits including habitual short sleep duration as well as irregular work schedules (e.g. night shift work) have been correlated with lower cognitive performance and increased risk of having metabolic syndrome (MetS). However evidence is not conclusive regarding the above mentioned associations. The aim of this thesis was to investigate associations of diet, sleep, and shift work with metabolic health or cognitive performance in two Swedish cohorts.

In Paper I and II we examined whether the dietary intake of omega-3 fatty acids and adherence to MeDi were related to measures of brain health in elderly subjects. To this aim, we used scores from the 7-minute cognitive screening test (7MS) and brain volume determined by magnetic resonance imaging. In Paper I, self-reported dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) at age 70 was positively associated with cognitive performance and global gray matter volume at age 75. In Paper II, the fully-adjusted main analysis revealed that the MeDi score was not linked to measures of brain health. However, low intake of the MeDi component meat and meat products was associated with better performance on the 7MS and larger total brain volume.

Paper III and IV included subjects aged 45-75 years. In Paper III we demonstrated that current and recent former shift workers (including shifts outside traditional working hours during the past 5 years at the time of the survey) performed worse on the trail making test (TMT) than non-shift workers. The TMT is a test evaluating executive cognitive function, and the performance on this test decreases with age. In Paper IV, sleep duration, sleep disturbances, and sleep-disordered breathing were all linked to an increased prevalence of MetS. Some of the observed associations were age-specific. For example, whereas both short and long sleep durations were linked to a higher prevalence of MetS in younger individuals (<65 years), only long sleep duration did so in the older participants. Collectively, the findings of this thesis suggest that maintaining healthy dietary habits, having high-quality sleep, and following a regular work schedule may be recommended strategies to mitigate age-related morbidities.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2019. s. 58
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1532
Nyckelord
cognitive function, Mediterranean diet, omega-3 fatty acids, MRI, shift work history, sleep, metabolic syndrome
Nationell ämneskategori
Medicin och hälsovetenskap
Forskningsämne
Epidemiologi; Medicinsk vetenskap
Identifikatorer
urn:nbn:se:uu:diva-368737 (URN)978-91-513-0557-8 (ISBN)
Disputation
2019-03-07, A1:107a, BMC, Husargatan 3, Uppsala, 10:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2019-02-14 Skapad: 2019-01-17 Senast uppdaterad: 2019-02-18

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Titova, Olga ELindberg, EvaLind, LarsSchiöth, Helgi B.Benedict, Christian

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Titova, Olga ELindberg, EvaLind, LarsSchiöth, Helgi B.Benedict, Christian
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Funktionell farmakologiLung- allergi- och sömnforskningKardiovaskulär epidemiologi
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