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Treatment of idiopathic rhinitis with kinetic oscillations - a multi-centre randomized controlled study
Karolinska Inst, Div Otorhinolaryngol, Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
Skane Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Lund, Sweden.;Skane Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Malmo, Sweden..
Skane Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Lund, Sweden.;Skane Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Malmo, Sweden..
Skane Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Lund, Sweden.;Skane Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Malmo, Sweden..
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2016 (Engelska)Ingår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 136, nr 8, 852-859 s.Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Conclusions: The potential effects of KOS are still uncertain regarding the most effective air pressure to be used as well as the physiological effects on the nasal mucosa. The results of the study do not support a convincing treatment effect by KOS on IR. Objectives: Idiopathic rhinitis (IR) is a common disorder, affecting approximate to 10-20% of the population. A new method for treating IR, Kinetic Oscillation Stimulation (KOS), has been reported to have beneficial effects on total vasomotor symptom scores (TVRSS). The primary objective with this study was to evaluate if a mean pressure of 65 mbar, pressure amplitude of 100 mbar, and 68Hz treatment with KOS had a positive effect on total vasomotor symptom scores (TVRSS), as compared with a mean pressure of 65 mbar, pressure amplitude of 4 mbar, and 68Hz treatment in patients with idiopathic rhinitis. Methods: Two hundred and seven patients were randomized (Full Analysis Set, FAS) in the study, including five visits and lasting for approximate to 25 weeks. All patients had two treatment episodes, and all patients had at least one treatment, meant as active, with high amplitude pressure for 10min in each nostril. Group 1 had two such treatments, and Group 2 had one treatment with low amplitude pressure, initially meant as placebo, on one occasion. Because of numerical improvements in these two groups, a new control group, Group 3, was introduced. They had one new control treatment where the balloon was inserted into the nose, without any air inflation and without oscillations. Results: KOS treatment with high amplitude pressure did not have significant beneficial effects as compared to low amplitude pressure on TVRSS. Numerical improvements in TVRSS and SNOT 22 were found when comparing high and low amplitude pressure treatments with uninflated balloon treatment. However, this part of the study was initially single-blinded, and these results were secondary objectives.

Ort, förlag, år, upplaga, sidor
2016. Vol. 136, nr 8, 852-859 s.
Nyckelord [en]
Vasomotor rhinitis, non-allergic rhinitis, KOS, nasal obstruction, nasal congestion
Nationell ämneskategori
Oto-rino-laryngologi
Identifikatorer
URN: urn:nbn:se:uu:diva-308378DOI: 10.3109/00016489.2016.1155231ISI: 000380796800016PubMedID: 27052839OAI: oai:DiVA.org:uu-308378DiVA: diva2:1049622
Tillgänglig från: 2016-11-25 Skapad: 2016-11-25 Senast uppdaterad: 2016-11-25Bibliografiskt granskad

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