uu.seUppsala universitets publikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Numerous Ontogenetic Roads to Mantle Cell Lymphoma: Immunogenetic and Immunohistochemical Evidence
Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece.;Univ Athens, Sch Med, Dept Pathol, Athens, Greece..
Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Ctr Res & Technol Hellas CERTH, Inst Appl Biosci, Thessaloniki, Greece.
Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece..
Ctr Res & Technol Hellas CERTH, Inst Appl Biosci, Thessaloniki, Greece..
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: American Journal of Pathology, ISSN 0002-9440, E-ISSN 1525-2191, Vol. 187, nr 7, 1454-1458 s.Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

To obtain insight into the ontogeny of mantle cell lymphoma (MCL), we assessed 206 patients from a morphological, immunohistochemical, and immunogenetic perspective. Our series included nodal (n = 151), extranodal. (n = 28), and primary splenic (n = 27) MCL cases. Skewing of the immunoglobulin heavy variable (IGHV) gene repertoire was noted, with only four IGHV genes accounting for 46% of cases and approximately 70% of cases (107/154) bearing an imprint of somatic hypermutation (SHM) ranging from minimalto pronounced. Interestingly, a distinctive immunophenotypic and immunogenetic profile was identified for primary splenic MCL, which was enriched for DBA.44-positive cases (P < 0.001) and used the IGHV1-8 gene more frequently (P = 0.02) compared to nodal or extranodal cases, alluding to distinct immunopathogenetic and antigen selection processes. Expression of CD27 (considered a marker of activated B cells) was generally dissociated from SHM and was more prevalent in cases with no or minimal/borderline SHM. These findings support the idea that antigen drive is relevant for most MCL cases, although the specific antigens and the precise location of affinity maturation remain to be elucidated. Moreover, they raise the intriguing hypothesis of multiple cellular origins for MCL.

Ort, förlag, år, upplaga, sidor
ELSEVIER SCIENCE INC , 2017. Vol. 187, nr 7, 1454-1458 s.
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-328974DOI: 10.1016/j.ajpath.2017.02.017ISI: 000404320500003PubMedID: 28457696OAI: oai:DiVA.org:uu-328974DiVA: diva2:1140614
Tillgänglig från: 2017-09-12 Skapad: 2017-09-12 Senast uppdaterad: 2017-09-12Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Sundström, ChristerStamatopoulos, Kostas

Sök vidare i DiVA

Av författaren/redaktören
Sundström, ChristerStamatopoulos, Kostas
Av organisationen
Science for Life Laboratory, SciLifeLabInstitutionen för immunologi, genetik och patologi
I samma tidskrift
American Journal of Pathology
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 122 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf