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Demography and mating system shape the genome-wide impact of purifying selection in Arabis alpina
Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden..
Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden..
Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden..
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Växtekologi och evolution.
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2018 (Engelska)Ingår i: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 115, nr 4, s. 816-821Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Plant mating systems have profound effects on levels and structuring of genetic variation and can affect the impact of natural selection. Although theory predicts that intermediate outcrossing rates may allow plants to prevent accumulation of deleterious alleles, few studies have empirically tested this prediction using genomic data. Here, we study the effect of mating system on purifying selection by conducting population-genomic analyses on whole-genome resequencing data from 38 European individuals of the arctic-alpine crucifer Arabis alpina. We find that outcrossing and mixed-mating populations maintain genetic diversity at similar levels, whereas highly self-fertilizing Scandinavian A. alpina show a strong reduction in genetic diversity, most likely as a result of a postglacial colonization bottleneck. We further find evidence for accumulation of genetic load in highly self-fertilizing populations, whereas the genome-wide impact of purifying selection does not differ greatly between mixed-mating and outcrossing populations. Our results demonstrate that intermediate levels of outcrossing may allow efficient selection against harmful alleles, whereas demographic effects can be important for relaxed purifying selection in highly selfing populations. Thus, mating system and demography shape the impact of purifying selection on genomic variation in A. alpina. These results are important for an improved understanding of the evolutionary consequences of mating system variation and the maintenance of mixed-mating strategies.

Ort, förlag, år, upplaga, sidor
NATL ACAD SCIENCES , 2018. Vol. 115, nr 4, s. 816-821
Nyckelord [en]
self-fertilization, demographic history, bottleneck, fitness effects, genetic load
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Biologiska vetenskaper
Identifikatorer
URN: urn:nbn:se:uu:diva-343798DOI: 10.1073/pnas.1707492115ISI: 000423097800070PubMedID: 29301967OAI: oai:DiVA.org:uu-343798DiVA, id: diva2:1187484
Forskningsfinansiär
Swedish National Infrastructure for Computing (SNIC), snic2014-1-194, b2013022, b2013237VetenskapsrådetScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Tillgänglig från: 2018-03-05 Skapad: 2018-03-05 Senast uppdaterad: 2018-03-05Bibliografiskt granskad

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