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Long-term mechanical properties of a low-modulus bone cement for the treatment of vertebral compression fractures
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.ORCID-id: 0000-0003-4139-6913
(Engelska)Ingår i: Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm)) In press
Nyckelord [en]
Acrylic bone cement, low-modulus, elastic modulus, compression, fatigue, vertebroplasty
Nationell ämneskategori
Materialteknik
Forskningsämne
Teknisk fysik med inriktning mot materialvetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-349059OAI: oai:DiVA.org:uu-349059DiVA, id: diva2:1199300
Tillgänglig från: 2018-04-20 Skapad: 2018-04-20 Senast uppdaterad: 2018-04-20
Ingår i avhandling
1. Bone-compliant cements for vertebral augmentation
Öppna denna publikation i ny flik eller fönster >>Bone-compliant cements for vertebral augmentation
2018 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Acrylic bone cement based on poly(methyl methacrylate) (PMMA) is commonly used during vertebral augmentation procedures for the treatment of osteoporosis-induced vertebral compression fractures. However, the high stiffness of the cement compared to that of the surrounding trabecular bone is presumed to facilitate the formation of new fractures shortly after surgery. The aim of the thesis was to develop and evaluate a PMMA-based bone cement that better matches the mechanical properties of vertebral trabecular bone. To fulfill this objective, different compounds were added to the initial formulation of bone cement to modify its functional properties. Linoleic acid (LA) was found to give the best combination of strength and stiffness without negative effects on the handling properties and its use was therefore further investigated. In particular, different application-specific mechanical properties of LA-modified cement as well as itsin vivoperformance in an ovine model were assessed. 

In summary, LA-modified cement exhibited bone-compliant mechanical properties immediately after incorporation of the additive, as well as adequate handling properties, in particular a lower polymerization temperature and appropriate setting time. The screw pullout strength from low-modulus cement was substantially reduced compared to regular PMMA cement, but comparable to some calcium phosphate based cements. The fatigue limit of LA-modified cement was considerably lower compared to regular PMMA bone cement when tested in physiological solution, but still higher than stresses measured in the spine during daily activities. The modified cement displayed similar inflammatory response in vivoto conventional cement, with no evidence of additional cytotoxicity due to the presence of LA. Finally, it was possible to sterilize the additive without significantly compromising its function in the PMMA cement.

The results from this thesis support further evaluation of the material towards the intended clinical application. 

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2018. s. 92
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1676
Nyckelord
bone cement, low modulus, vertebroplasty
Nationell ämneskategori
Materialteknik
Forskningsämne
Teknisk fysik med inriktning mot materialvetenskap
Identifikatorer
urn:nbn:se:uu:diva-349028 (URN)978-91-513-0351-2 (ISBN)
Disputation
2018-06-07, Häggsalen, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 09:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2018-05-16 Skapad: 2018-04-20 Senast uppdaterad: 2018-10-08

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