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High birth weight was associated with increased radial artery intima thickness but not with other investigated cardiovascular risk factors in adulthood
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Pediatrisk inflammationsforskning.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Gynekologisk endokrinologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Perinatal, neonatal och barnkardiologisk forskning.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Pediatrisk inflammationsforskning.
2018 (Engelska)Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 12, s. 2152-2157Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

AIM: This study investigated whether a high birth weight was associated with increased risk factors for cardiovascular disease when Swedish adults reached 34-40.

METHODS: We studied 27 subjects born at Uppsala University Hospital in 1975-1979, weighing at least 4500 g, and compared them with 27 controls selected by the Swedish National Board of Welfare with birth weights within ±1 standard deviations scores and similar ages and gender. The study included body mass index (BMI), blood pressure, lipid profile, haemoglobin A1c (HbA1c), C-reactive protein (CRP) and high-frequency ultrasound measurements of intima-media thickness, intima thickness (IT) and intima:media ratio of the carotid and radial arteries.

RESULTS: Subjects with a high birth weight did not differ from controls with regard to BMI, blood pressure, lipid profile, high-sensitivity CRP, HbA1c or carotid artery wall dimensions. However, their radial artery intima thickness was 37% greater than the control group and their intima:media ratio was 44% higher.

CONCLUSION: Our findings indicate that a high birth weight was associated with increased radial artery intima thickness, but not with other investigated cardiovascular risk factors, at 34-40 years of age. The clinical implications of these findings should be investigated further, especially in subjects born with a very high birth weight.

Ort, förlag, år, upplaga, sidor
2018. Vol. 12, s. 2152-2157
Nyckelord [en]
Cardiovascular risk factors, High birth weight, Intima thickness, Intima:media ratio, Large for gestational age
Nationell ämneskategori
Pediatrik Kardiologi
Identifikatorer
URN: urn:nbn:se:uu:diva-364690DOI: 10.1111/apa.14414ISI: 000449638100022PubMedID: 29791055OAI: oai:DiVA.org:uu-364690DiVA, id: diva2:1259939
Forskningsfinansiär
Novo NordiskTillgänglig från: 2018-10-31 Skapad: 2018-10-31 Senast uppdaterad: 2019-01-22Bibliografiskt granskad
Ingår i avhandling
1. Long-term metabolic effects of a high birth weight
Öppna denna publikation i ny flik eller fönster >>Long-term metabolic effects of a high birth weight
2019 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The intrauterine environment influences foetal growth as well as future response to risk factors for disease. This occurs partly through epigenetic mechanisms. Thus, birth weight is a possible risk marker of adult disease. Low birth weight is a well-known risk factor for adult disease, particularly when associated with obesity and a U-shaped relationship between birth weight and several metabolic diseases has been suggested.

In this thesis we investigated associations between a high birth weight and risk of adult disease, e.g. obesity, cardiovascular disease, type 2 diabetes and gestational diabetes.

By analyses of national register data on 759 999 subjects up to the age of 37 years, we could demonstrate an increased risk of type 2 diabetes in males, but not in females, with a high birth weight (>2 SDS). The increase was particularly pronounced in males with a birth weight >3 SDS. There was an association between high birth weight and obesity in males and females, but no such relation was seen for hypertension or serum lipid abnormalities.

In a clinical study, 27 cases with a birth weight ≥4 500 grams were compared with 27 controls with normal birth weight, regarding risk factors for cardiovascular disease and diabetes. The cases had a greater radial artery intima thickness and intima:media ratio compared with the controls indicating early atherosclerotic changes. Body mass index, body composition, insulin sensitivity, lipid profiles, blood pressure, resting energy expenditure and respiratory quotient did not differ between cases and controls, but females with a high birth weight had a more disadvantageous distribution of body fat.

In order to investigate associations between birth weight and pregnancy outcomes, register data on 305 893 females was analysed. The results demonstrated an association between the female´s own birth weight and offspring birth weight. A high maternal birth weight was associated with increased risk of obesity. The risk of gestational diabetes was increased in females with a low, but not a high birth weight.

In conclusion, subjects with a moderately high birth weight did not differ substantially from those with a normal birth weight regarding risk factors for cardiovascular disease. However, differences in arterial wall dimensions were demonstrated in a clinical investigation, and there were differences in BMI and risk of type 2 diabetes on a population level. Since risks are most pronounced in subjects with a birth weight >3 SDS, this group is in particular need of follow up and disease preventive measures.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2019. s. 48
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1525
Nyckelord
Body composition, Cardiovascular risk factors, Gestational diabetes, Glucose tolerance, High birth weight, Insulin sensitivity, Large for gestational age, Obesity, Offspring macrosomia, Type 2 diabetes
Nationell ämneskategori
Pediatrik
Forskningsämne
Endokrinologi och Diabetologi
Identifikatorer
urn:nbn:se:uu:diva-369263 (URN)978-91-513-0534-9 (ISBN)
Disputation
2019-02-13, Rosénsalen, Akademiska Barnsjukhuset, Ing 95/96 NBV, Uppsala, 09:15 (Svenska)
Opponent
Handledare
Tillgänglig från: 2019-01-22 Skapad: 2018-12-12 Senast uppdaterad: 2019-02-18

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Johnsson, Inger WNaessén, TordAhlsson, FredrikGustafsson, Jan

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Pediatrisk inflammationsforskningGynekologisk endokrinologiPerinatal, neonatal och barnkardiologisk forskning
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