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Microvascular capillary assessment in relation to forearm blood flow
Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk epidemiologi.ORCID-id: 0000-0003-2335-8542
Karolinska Univ Hosp, Div Clin Chem, Stockholm, Sweden.
Karolinska Univ Hosp, Dept Med, Stockholm, Sweden.ORCID-id: 0000-0003-2885-211X
2019 (Engelska)Ingår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 39, nr 5, s. 322-326Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective To study whether vascular reactivity as assessed by the methods forearm blood flow (FBF) and postocclusive reactive hyperaemia (PRH) in the nail fold was related as a measure of endothelium-dependent vasodilation in the microcirculation. Methods Microvascular reactivity was assessed in forearm blood flow and in the nail fold by vital capillaroscopy of individual microvessels as postocclusive reactive hyperaemia. Vascular reactivity was assessed at baseline (n = 25) as well as after infusion of acetylcholine and of sodium nitroprusside (n = 13). We also performed a multivariate regression analysis to assess whether forearm blood flow or flow-mediated dilatation related to postocclusive reactive hyperaemia. Results This study showed a distinct microvascular response to both acetylcholine (endothelium-dependent vasodilation) and sodium nitroprusside (endothelium-independent vasodilation) during forearm blood flow assessment and postocclusive reactive hyperaemia assessment in the nail fold (n = 13). These changes were inversely related (r- = -0 center dot 57; P<0 center dot 05). Conclusions Forearm blood flow was inversely correlated to postocclusive reactive hyperaemia. Postocclusive reactive hyperaemia was shortened after infusion with both acetylcholine and sodium nitroprusside. This occurred in parallel with the expected increase in forearm blood flow, conceivably reflecting that both methods can be used to assess endothelium-dependent vasodilation in the microcirculation.

Ort, förlag, år, upplaga, sidor
WILEY , 2019. Vol. 39, nr 5, s. 322-326
Nyckelord [en]
capillaroscopy, endothelial function, forearm blood flow, microcirculation, postocclusive reactive hyperaemia
Nationell ämneskategori
Fysiologi
Identifikatorer
URN: urn:nbn:se:uu:diva-393648DOI: 10.1111/cpf.12575ISI: 000479117100004PubMedID: 31074581OAI: oai:DiVA.org:uu-393648DiVA, id: diva2:1354572
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Knut och Alice Wallenbergs StiftelseTillgänglig från: 2019-09-25 Skapad: 2019-09-25 Senast uppdaterad: 2019-09-25Bibliografiskt granskad

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