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The impact of birth weight on coronary heart disease morbidity and mortality in a birth cohort followed up for 85 years: a population-based study of men born in 1913
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och klinisk epidemiologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och klinisk epidemiologi.
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2004 (Engelska)Ingår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 256, nr 6, s. 472-81Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives. To analyse whether there is a relationship between birth weight on the one hand and coronary heart disease (CHD) and cardiovascular disease (CVD) mortality and morbidity on the other, whether such a relationship is influenced by potential modifying factors from the time of birth, adult height and the presence of diabetes, and what significance these possible associations might have for the CHD and CVD rates in the general population.

Design. Population-based birth cohort.

Setting. Sweden.

Subjects. A total of 1319 singleton men born in 1913, surviving until age 20 and from then on followed until 85 years of age.

Main outcome measures. CHD and CVD mortality and morbidity events.

Results. The gestational age adjusted CHD and CVD mortality and morbidity hazard ratios were virtually unaffected by birth weight. Taking possible effect-modifying variables into account did not change the results. The population attributable risk percentage for CHD and CVD mortality and morbidity due to a birth weight ≤3000 g was 1% or less.

Conclusions. Birth weight did not significantly affect CHD or CVD mortality or morbidity. A birth weight ≤3000 g contributes little to the burden of CHD and CVD on a community level.

Ort, förlag, år, upplaga, sidor
2004. Vol. 256, nr 6, s. 472-81
Nyckelord [en]
adult height, birth weight, cardiovascular disease, coronary heart disease, diabetes
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-93553DOI: 10.1111/j.1365-2796.2004.01412.xOAI: oai:DiVA.org:uu-93553DiVA, id: diva2:167070
Tillgänglig från: 2005-10-13 Skapad: 2005-10-13 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
Ingår i avhandling
1. The Impact of Birth Weight on Cardiovascular Risk Factors, Coronary Heart Disease and Prostate Cancer: Population-based Studies of Men Born in 1913 and Followed up Until Old Age
Öppna denna publikation i ny flik eller fönster >>The Impact of Birth Weight on Cardiovascular Risk Factors, Coronary Heart Disease and Prostate Cancer: Population-based Studies of Men Born in 1913 and Followed up Until Old Age
2005 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Objectives. To study whether birth weight (BW) was correlated to cardiovascular risk factors, coronary heart disease (CHD), cardiovascular disease (CVD), and prostate cancer (PCA) at adult ages, whether a possible relationship depended on mediating factors from birth time, hereditary circumstances, and adult life variables, and what importance possible associations might have for the rate of the complaint in the general population.

Material and methods. Population-based cohorts of men born in 1913 and followed up until old age. Risk of outcome was estimated using Cox’s and Poisson regressions. The results were transformed to population attributable risk percentage (PAR%) of the complaint that could be attributed to low or high BW, given causality between exposure and outcome.

Results. After adjustment for the influence of covariates, systolic blood pressure at age 50 decreased by 3.7 mmHg per 1000 g increase in BW, the prevalence of antihypertensive treatment decreased by 32%, diabetes by 53%, serum total cholesterol decreased by 0.20 mmol L-1, and being in top quintile of serum cholesterol decreased by 23%. The adjusted risks were somewhat more marked relative to the crude risks. CHD and CVD incidence and mortality were virtually unaffected by BW. In the general population, the risk percentage attributable to a BW ≤3000 g was 18% for diabetes, 2.5% for cholesterol, and ≤1% for antihypertensive treatment and CHD and CVD incidence and mortality.

PCA incidence and mortality risk increased by 62% and 82%, respectively, among those whose BW was ≥4250 g compared with those whose BW was 3001-4249 g. The risk percentages attributable to a BW ≥4250 g in the general population for PCA incidence and mortality were 7.8% and 10.8%.

Conclusions. Low BW seemed to affect cardiovascular risk factors but not incidence and mortality from CHD and CVD. A high proportion of diabetes on the community level could be attributed to low BW, while the proportional burden of other cardiovascular complaints that could be attributed to low BW was modest. PCA incidence and mortality seemed to be affected by high BW.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2005. s. 74
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 77
Nyckelord
birth weight, coronary heart disease, cardiovascular disease, diabetes, blood pressure, hypertension, cholesterol, prostate cancer, cohort studies, follow-up studies
Nationell ämneskategori
Allmänmedicin
Identifikatorer
urn:nbn:se:uu:diva-6005 (URN)91-554-6359-2 (ISBN)
Disputation
2005-11-03, Rudbecksalen, Rudbecklaboratoriet, Uppsala Science Park, Uppsala, 13:15 (Engelska)
Opponent
Handledare
Tillgänglig från: 2005-10-13 Skapad: 2005-10-13 Senast uppdaterad: 2018-01-13Bibliografiskt granskad

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Eriksson, MargarethaWallander, Mari-AnnSvärdsudd, Kurt

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