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Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging
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2010 (Engelska)Ingår i: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 52, nr 4, s. 307-317Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

INTRODUCTION: The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. METHODS: A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no susceptibility artefacts and 2 = extensive susceptibility artefacts (maximum diameter > 2 cm)). A quantitative analysis was performed with normalised tumour blood flow values (ASL nTBF, DSC nTBF): mean value for region of interest (ROI) in an area with maximum signal enhancement/the mean value for ROIs in cerebellum. RESULTS: There was no difference in total visual score for signal enhancement between PC ASL and DSC relative cerebral blood flow (p = 0.12). ASL had a lower susceptibility-artefact score than DSC-MRI (p = 0.03). There was good correlation between DSC nTBF and ASL nTBF values with a correlation coefficient of 0.82. CONCLUSION: PC ASL is an alternative to DSC-MRI for the evaluation of perfusion in brain tumours. The method has fewer susceptibility artefacts than DSC-MRI and can be used in patients with renal failure because no contrast injection is needed.

Ort, förlag, år, upplaga, sidor
2010. Vol. 52, nr 4, s. 307-317
Nyckelord [en]
Magnetic resonance imaging, Perfusion, ASL, DSC-MRI, Brain neoplasms
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Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-124861DOI: 10.1007/s00234-009-0616-6ISI: 000275422000006PubMedID: 19841916OAI: oai:DiVA.org:uu-124861DiVA, id: diva2:318063
Tillgänglig från: 2010-05-06 Skapad: 2010-05-06 Senast uppdaterad: 2017-12-12Bibliografiskt granskad

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Larsson, Elna-Marie

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