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Explorative study on the predictive value of systematic inflammatory and metabolic markers on weight loss in head and neck cancer patients undergoing radiotherapy
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. (Gastroenterologi/Hellström)
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2010 (Engelska)Ingår i: Supportive Care in Cancer, ISSN 0941-4355, E-ISSN 1433-7339, Vol. 18, nr 11, s. 1385-1391Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose

This study aimed to explore the predictive value of systematic inflammatory and metabolic markers in head and neck (H&N) cancer patients during radiotherapy (RT).

Methods

Twenty-seven patients were evaluated. The protocol included serial blood tests [highly sensitive C-reactive protein (hsCRP), albumin, insulin-like growth factor 1 (IGF-1), IGF binding protein 1 (IGFBP-1) and ghrelin], measurements of body weight and assessment of oral mucositis.

Results

The mean nadir of weight loss was observed at the end of RT. At the time of diagnosis, mean hsCRP was 5.2 +/- 1.0 mg/L. HsCRP significantly increased during RT and decreased during the post-RT period. Mean maximum hsCRP was 35.8 +/- 8.5 mg/L, with seven patients reaching >40 mg/L. A numerical decrease of albumin (by 18.2%) and only small changes in IGF-1, IGFBP-1 and ghrelin levels were observed. None of the metabolic parameters was significantly associated with weight loss.

Conclusions

HsCRP increased in response to RT for H&N cancer as a sign of irradiation-induced inflammation. Weight loss was not preceded by changes of the metabolic parameters, indicating that assessment of the blood markers used in this study is of little value. Regular body weight measurement and assessment of oral mucositis are feasible, cheap and important procedures to control the metabolic homeostasis during RT.

Ort, förlag, år, upplaga, sidor
2010. Vol. 18, nr 11, s. 1385-1391
Nyckelord [en]
Highly sensitive C-reactive protein, Albumin, Insulin-like growth factor 1, Insulin-like growth factor binding protein 1, Ghrelin, Weight loss
Nationell ämneskategori
Gastroenterologi
Forskningsämne
Medicinsk vetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-145217DOI: 10.1007/s00520-009-0758-4ISI: 000282182500004PubMedID: 19830461OAI: oai:DiVA.org:uu-145217DiVA, id: diva2:395773
Tillgänglig från: 2011-02-08 Skapad: 2011-02-07 Senast uppdaterad: 2017-12-11Bibliografiskt granskad

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Hellström, Per M.

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Supportive Care in Cancer
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