uu.seUppsala universitets publikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Effects of moderate red wine consumption on liver fat and blood lipids: a prospective randomized study
Visa övriga samt affilieringar
2011 (Engelska)Ingår i: Annals of Medicine, ISSN 0785-3890, E-ISSN 1365-2060, Vol. 43, nr 7, s. 545-554Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: There have been no human prospective randomized studies of the amount of alcohol that can induce hepatic steatosis.

Methods: Thirty-two healthy women and twelve healthy men (34 ± 9 years of age) were randomized to consume 150 ml of red wine/day for women (16 g ethanol/day) or double that amount for men (33 g ethanol/day), or to alcohol abstention for 90 days. Participants underwent proton-nuclear magnetic-resonance spectroscopy for measurement of hepatic triglyceride content (HTGC). Blood samples for assessment of cardiovascular risk were drawn before and after the intervention.

Results: After exclusion of three subjects with steatosis at baseline a trend towards increased HTGC was apparent for red wine (before median: 1.1%, range 0.2-3.9%, after median: 1.1%, range 0.5-5.2 %, P = 0.059) a difference that was statistically significant compared with abstainers (p = 0.02). However, no subject developed hepatic steatosis. Low-density lipoprotein (LDL)-cholesterol was lowered by red wine (-0.3 mmol/l, SE -0.1, 95% CI -0.6 to -0.04).

Conclusions: Moderate consumption of red wine during three months increased HTGC in subjects without steatosis at baseline. However, since not a single participant developed steatosis we suggest that the threshold of alcohol consumption to define nonalcoholic fatty liver disease should not be lower than the amount in our study.

Ort, förlag, år, upplaga, sidor
2011. Vol. 43, nr 7, s. 545-554
Nyckelord [en]
alcohol, hepatic triglyceride content, NAFLD
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-154256DOI: 10.3109/07853890.2011.588246ISI: 000295127900005PubMedID: 21599573OAI: oai:DiVA.org:uu-154256DiVA, id: diva2:419701
Tillgänglig från: 2011-05-27 Skapad: 2011-05-27 Senast uppdaterad: 2018-05-30Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Johansson, LarsKullberg, JoelAhlström, Håkan

Sök vidare i DiVA

Av författaren/redaktören
Johansson, LarsKullberg, JoelAhlström, Håkan
Av organisationen
Enheten för radiologi
I samma tidskrift
Annals of Medicine
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 449 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf