uu.seUppsala universitets publikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Randomized comparison of the influence of dietary management and/or physical exercise on ovarian function and metabolic parameters in overweight women with polycystic ovary syndrome
Visa övriga samt affilieringar
2011 (Engelska)Ingår i: Fertility and Sterility, ISSN 0015-0282, E-ISSN 1556-5653, Vol. 96, nr 6, s. 1508-1513Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective:

To compare the influence of dietary management and/or physical exercise on ovarian function and metabolic variables in women with polycystic ovary syndrome (PCOS).

Design:

Randomized 4-month trial with three interventions and a long-term follow-up.

Setting:

Women's health clinical research unit at a university hospital.

Patient(s):

Fifty-seven overweight/obese women with PCOS.

Intervention(s):

Dietary management, physical exercise, or both, using programs individually adapted and supervised by a dietician and/or a physical therapist. Main

Outcome Measure(s):

Ovarian function, endocrinologic, and metabolic status and body composition.

Result(s):

On average, body mass index was reduced 6% by the dietary management, 3% by the exercise, and 5% by the combined interventions. Lower body fat and lean body mass were significantly decreased in the dietary groups, whereas upper body fat was lowered and lean body mass maintained by exercise alone. The menstrual pattern was significantly improved in 69% and ovulation confirmed in 34% of the patients, with no differences among the groups. The strongest predictor of resumed ovulation was a high serum level of insulin-like growth factor-binding protein 1 after the intervention. Follow-up of one-half of the patients for a median of 2.8 years revealed sustained weight reduction and improvement in menstrual pattern.

Conclusion(s):

Dietary management and exercise, alone or in combination, are equally effective in improving reproductive function in overweight/obese women with PCOS. The underlying mechanisms appear to involve enhanced insulin sensitivity. Supportive individualized programs for lifestyle change could exert long-term beneficial effects.

Ort, förlag, år, upplaga, sidor
2011. Vol. 96, nr 6, s. 1508-1513
Nyckelord [en]
PCOS, obesity, diet, physical activity, lifestyle intervention, ovulation, body composition, weight loss
Nationell ämneskategori
Endokrinologi och diabetes
Forskningsämne
Medicinsk vetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-168414DOI: 10.1016/j.fertnstert.2011.09.006ISI: 000298119700050OAI: oai:DiVA.org:uu-168414DiVA, id: diva2:499274
Tillgänglig från: 2012-02-13 Skapad: 2012-02-10 Senast uppdaterad: 2017-12-07Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltext

Personposter BETA

Hellström, Per Martin

Sök vidare i DiVA

Av författaren/redaktören
Hellström, Per Martin
Av organisationen
Institutionen för medicinska vetenskaper
I samma tidskrift
Fertility and Sterility
Endokrinologi och diabetes

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 398 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf