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Transcription Factor Activating Protein-2β (TFAP-2β) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Neuropsykofarmakologi.
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2014 (Norska)Ingår i: European Child and Adolescent Psychiatry, ISSN 1018-8827, E-ISSN 1435-165X, Vol. 23, nr 4, s. 207-217Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The Transcription Factor Activating Protein-2β (TFAP-2β) gene has been shown to influence monoaminergic neurotransmission, and several genes important for monoaminergic function have binding sites for TFAP-2β. Familial studies of attention deficit hyperactivity disorder (ADHD) suggest a hereditary-determined subtype of ADHD with comorbid depression. We examined a functional variation of the TFAP-2β gene in the context of co-occurring symptoms of ADHD and depression in two independent population-based samples of adolescents (Group A, n = 175 and Group B, n = 1,506) from Sweden. Results indicated 6.1 to 7.8 % of adolescents screened positively for ADHD and depression symptoms. Symptoms of depression were more common among girls who screened positively for ADHD and did not carry the nine-repeat allele of the TFAP-2β intron 1 Variable Number Tandem Repeat (VNTR) polymorphism. The presence of the nine-repeat variant of the TFAP-2β intron 1 VNTR appears to protect girls with ADHD symptoms from the co-expression of symptoms of depression.

Ort, förlag, år, upplaga, sidor
2014. Vol. 23, nr 4, s. 207-217
Nyckelord [en]
attention deficit hyperactivity disorder, depression, adolescents, comorbitidy, transcription factor AP-2β, 
Nationell ämneskategori
Psykiatri
Forskningsämne
Barn- och ungdomspsykiatri
Identifikatorer
URN: urn:nbn:se:uu:diva-219063DOI: 10.1007/s00787-013-0450-6ISI: 000334175700004PubMedID: 23824473OAI: oai:DiVA.org:uu-219063DiVA, id: diva2:699624
Tillgänglig från: 2014-02-28 Skapad: 2014-02-20 Senast uppdaterad: 2018-05-31Bibliografiskt granskad
Ingår i avhandling
1. Co-occurring Symptoms of Attention Deficit Hyperactivity Disorder and Depression: Sex, Aetiology, Help-Seeking and Assessment
Öppna denna publikation i ny flik eller fönster >>Co-occurring Symptoms of Attention Deficit Hyperactivity Disorder and Depression: Sex, Aetiology, Help-Seeking and Assessment
2014 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The general aim of the thesis was to contribute to the knowledge about co-occurring symptoms of ADHD and depression in adolescence, focusing on sex differences, as well as aetiology, help-seeking and assessment.

Studies I–III used epidemiological samples of self-reports from all students in Västmanland aged 15–16 and 17–18 years. Study I investigated the prevalence of co-occurring symptoms of ADHD and depression, as well as associations between co-occurring symptoms of ADHD and depression and one environmental stress factor; experience of sexual abuse. Study II examined associations between one biological factor—a polymorphism in TFAP-2βand co-occurring symptoms of ADHD with andco-occurringsymptoms of depression. Study III investigated the association between the parent–adolescent relationship and seeking help from specialized mental health services in relation to symptoms of ADHD and/or depression. Study IV was a clinical study among adolescent psychiatric patients that compared self-reported ADHD symptoms via the Adult ADHD Self-Report Scale–Adolescent version (ASRS-A) and the Adult ADHD Self-Report Scale–Adolescent–Screening version (ASRS-A-S) with an ADHD diagnosis determined by the gold-standard method; the Kiddie Schedule of Affective Disorders and Schizophrenia diagnostic interview.

Studies I–III showed that the phenotype of co-occurring symptoms of ADHD and depression is frequent, with a distinct preponderance among girls. Approximately 50% of both boys and girls with co-occurring symptoms of ADHD and depression had also experienced sexual abuse, indicating that this is a group with multiple risk factors for long-term impaired mental health.

Results also support biological sex differences because girls with symptoms of ADHD and a common polymorphism of TFAP-2β (absence of a 9 repeat) reported more symptoms of depression, but boys did not.

Further, only 5% of the adolescents with symptoms of ADHD and/or depression sought help from specialized mental health services. The co-occurrence of symptoms of ADHD and depression was a stronger predictor of help-seeking than all other psychosocial factors investigated, including secure attachment cognitions styles to parents. Among help-seeking girls, co-occurring symptoms of ADHD and depression were more common than symptoms of ADHD without co-occurring symptoms of depression.

The ASRS-A/ASRS-A-S showed promising psychometric properties for further validation in adolescentsresults as a screening tool for use in adolescents.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2014. s. 90
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 976
Nyckelord
Attention deficit hyperactivity disorder, depression, adolescent, sex, sexual abuse, transcription factor AP-2β, help-seeking, attachment object, validation study
Nationell ämneskategori
Medicin och hälsovetenskap
Forskningsämne
Barn- och ungdomspsykiatri
Identifikatorer
urn:nbn:se:uu:diva-219389 (URN)978-91-554-8892-5 (ISBN)
Disputation
2014-04-11, Aros Congress Center, Munkgatan 7, Västerås, 13:15 (Svenska)
Opponent
Handledare
Tillgänglig från: 2014-03-21 Skapad: 2014-02-28 Senast uppdaterad: 2014-04-29

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Nilsson, Kent W.Sonnby, KarinComasco, EricaLeppert, JerzyOreland, Lars

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Nilsson, Kent W.Sonnby, KarinComasco, EricaLeppert, JerzyOreland, Lars
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