Long-term retention of neurotoxic ß-carbolines in brain neuromelaninVisa övriga samt affilieringar
2003 (Engelska)Ingår i: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 111, nr 2, s. 141-157Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
beta-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of beta-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. beta-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of 3H-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these beta-carbolines to dopamine-melanin and melanin granules from Sepia officinalis was examined. The results revealed a high affinity binding to melanin and a long-term retention (up to 30 days) in pigmented tissues, including neuromelanin-containing neurons of frogs after a single injection. The role of long-term exposure to food-related beta-carbolines and a retention of these compounds in pigment-containing neurons in the induction of idiopathic Parkinson's disease should be further considered.
Ort, förlag, år, upplaga, sidor
2003. Vol. 111, nr 2, s. 141-157
Nyckelord [en]
beta-Carbolines, parkinsonism, neuromelanin, harman, norharman, Parkinson's disease, dopamine–melanin, Sepia officinalis
Nationell ämneskategori
Farmaceutiska vetenskaper
Identifikatorer
URN: urn:nbn:se:uu:diva-64767DOI: 10.1007/s00702-003-0080-0PubMedID: 14767717OAI: oai:DiVA.org:uu-64767DiVA, id: diva2:92678
2005-05-262005-05-262018-01-10Bibliografiskt granskad