Transcriptomics resources of human tissues and organsVisa övriga samt affilieringar
2016 (Engelska)Ingår i: Molecular Systems Biology, ISSN 1744-4292, E-ISSN 1744-4292, Vol. 12, nr 4, artikel-id 862Artikel, forskningsöversikt (Refereegranskat) Published
Resurstyp
Text
Abstract [en]
Quantifying the differential expression of genes in various human organs, tissues, and cell types is vital to understand human physiology and disease. Recently, several large-scale transcriptomics studies have analyzed the expression of protein-coding genes across tissues. These datasets provide a framework for defining the molecular constituents of the human body as well as for generating comprehensive lists of proteins expressed across tissues or in a tissue-restricted manner. Here, we review publicly available human transcriptome resources and discuss body-wide data from independent genome-wide transcriptome analyses of different tissues. Gene expression measurements from these independent datasets, generated using samples from fresh frozen surgical specimens and postmortem tissues, are consistent. Overall, the different genome-wide analyses support a distribution in which many proteins are found in all tissues and relatively few in a tissue-restricted manner. Moreover, we discuss the applications of publicly available omics data for building genome-scale metabolic models, used for analyzing cell and tissue functions both in physiological and in disease contexts.
Ort, förlag, år, upplaga, sidor
2016. Vol. 12, nr 4, artikel-id 862
Nyckelord [en]
genome-scale metabolic models, proteomics, transcriptomics
Nationell ämneskategori
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Identifikatorer
URN: urn:nbn:se:uu:diva-299282DOI: 10.15252/msb.20155865ISI: 000374497500001PubMedID: 27044256OAI: oai:DiVA.org:uu-299282DiVA, id: diva2:949189
Forskningsfinansiär
Knut och Alice Wallenbergs Stiftelse2016-07-182016-07-182017-11-28Bibliografiskt granskad