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High in-plane resolution T2-weighted magnetic resonance imaging of acute myocardial ischemia in pigs using the intravascular contrast agent NC100150 injection.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för radiologi, onkologi och strålningsvetenskap, Enheten för radiologi. (Ahlström)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. (Kardiologi)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för radiologi, onkologi och strålningsvetenskap, Enheten för radiologi. (Ahlström)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för radiologi, onkologi och strålningsvetenskap, Enheten för radiologi. (Ahlström)
2004 (engelsk)Inngår i: Investigative Radiology, ISSN 0020-9996, E-ISSN 1536-0210, Vol. 39, nr 8, s. 470-478Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Rationale and Objectives: The intravascular contrast agent NC100150 injection was tested for its ability to demarcate nonperfused myocardium in a porcine model of coronary occlusion.

Materials and Methods: A T2-weighted fast spin echo sequence was acquired ex vivo and in vivo during first pass and steady-state circulation of the contrast agent in 2 dosages (2 and 5 mg Fe/kg bw) or saline.

Results: Ex vivo, in the high-dose group, the volume of nonperfused myocardium determined from T2-weighted images was 99% of that determined from photographs where perfused myocardium stained with fluorescein. A significantly higher contrast to noise ratio between perfused and nonperfused myocardium was found (both ex and in vivo in steady state) compared with the control group. During first pass, a significant reduction in signal intensity (74 ± 18%) was found in perfused myocardium after contrast injection.

Conclusion: NC100150 injection, combined with T2-weighted turbo spin echo imaging, allowed detailed visualization of non-perfused myocardium in the steady state, which corresponded to the area at risk as determined by fluorescein.

sted, utgiver, år, opplag, sider
2004. Vol. 39, nr 8, s. 470-478
Emneord [en]
Animals, Contrast Media/administration & dosage, Coronary Circulation, In Vitro, Injections; Intravenous, Iron/administration & dosage/*diagnostic use, Magnetic Resonance Imaging/methods, Myocardial Infarction/*diagnosis/pathology, Myocardium/pathology, Oxides/administration & dosage/*diagnostic use, Research Support; Non-U.S. Gov't, Swine
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URN: urn:nbn:se:uu:diva-72804PubMedID: 15257208OAI: oai:DiVA.org:uu-72804DiVA, id: diva2:100715
Tilgjengelig fra: 2005-09-26 Laget: 2005-09-26 Sist oppdatert: 2017-12-14bibliografisk kontrollert

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