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Type 1 diabetes is associated with increased cyclooxygenase- and cytokine-mediated inflammation
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap. (Clinical Nutrition)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap. (Clinical Nutrition)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap. (Clinical Nutrition)
Vise andre og tillknytning
2005 (engelsk)Inngår i: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 28, nr 6, s. 1371-1375Artikkel i tidsskrift (Fagfellevurdert) Published
Fritextbeskrivning
Abstract [en]

OBJECTIVE: The extent of involvement of cyclooxygenase (COX)-mediated inflammation in type 1 diabetes is unknown, and the association between the COX- and cytokine-mediated inflammatory responses in type 1 diabetes is not fully understood.

RESEARCH DESIGN AND METHODS: Plasma high-sensitivity C-reactive protein (CRP), 24-h urinary and plasma 15-keto-dihydro-prostaglandin F(2alpha) (a metabolite of prostaglandin F(2alpha) [PGF(2alpha)] and an indicator of COX-mediated inflammation), serum amyloid protein A (SAA), and interleukin (IL)-6 (indicators of inflammation) were measured in 38 subjects with type 1 diabetes and 41 healthy age- and sex-matched control subjects.

RESULTS: The inflammatory indicators (urinary 15-keto-dihydro-PGF(2alpha), P < 0.01; IL-6, P < 0.04) were increased in men with diabetes. CRP and SAA did not show any significant difference between the diabetic and the control subjects. Urinary levels of 15-keto-dihydro-PGF(2alpha) correlated with the degree of glycemic control, HbA(1c) (r = 0.42, P < 0.0005). No correlation was found between the duration of diabetes and the inflammatory biomarkers or metabolic measurements.

CONCLUSIONS: These results suggest that an early low-grade inflammatory process reflected by elevated levels of PGF(2alpha) and IL-6 is involved in type 1 diabetes. Thus, both COX- and cytokine-mediated inflammatory pathways are significantly related to type 1 diabetes.

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2005. Vol. 28, nr 6, s. 1371-1375
Emneord [en]
Adult, Albuminuria/epidemiology, C-Reactive Protein/*analysis, Cytokines/blood, Diabetes Mellitus; Type 1/blood/*complications/*physiopathology, Diabetic Angiopathies/epidemiology, Dinoprost/analogs & derivatives/blood, Female, Humans, Hypertension/epidemiology, Inflammation/*epidemiology, Lipids/blood, Male, Reference Values, Regression Analysis, Research Support; Non-U.S. Gov't
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URN: urn:nbn:se:uu:diva-73980DOI: 10.2337/diacare.28.6.1371PubMedID: 15920054OAI: oai:DiVA.org:uu-73980DiVA, id: diva2:101891
Tilgjengelig fra: 2007-03-21 Laget: 2007-03-21 Sist oppdatert: 2020-04-29bibliografisk kontrollert

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Basu, SamarLarsson, AndersVessby, BengtBerne, Christian

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