uu.seUppsala universitets publikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Effects of acutely displaced sleep on testosterone.
Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap. Institutionen för medicinska vetenskaper.
2005 (Engelska)Ingår i: J Clin Endocrinol Metab, ISSN 0021-972X, Vol. 90, nr 8, s. 4530-5Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

CONTEXT: It is not yet clear whether the diurnal variation in testosterone is regulated by circadian or homeostatic (sleep) influences. OBJECTIVE: The present study tested whether testosterone is driven by a circadian-independent sleep effect by shifting sleep acutely to daytime in a 24-h sampling regiment. DESIGN, SETTING, AND PARTICIPANTS: In the sleep laboratory, seven healthy young men (age, 22-32 yr) participated in three conditions: habituation (sleep between 2300-0700 h), night sleep (2300-0700 h), and day sleep (0700-1500 h), the latter two in a balanced order. INTERVENTION AND MAIN OUTCOME MEASURE: Serum testosterone was, in all conditions, sampled by hourly blood drawing for 24 h during constant bed rest. RESULTS: Mean testosterone levels increased as a log-linear function of time (hours) across both sleep periods (b = 4.88; P < 0.001), from 15.3 +/- 2.1 to 25.3 +/- 2.2 nmol/liter during night sleep and from 17.3 +/- 2.1 to 26.4 +/- 2.9 nmol/liter during day sleep. Similarly, mean testosterone levels decreased with time (log-linear) awake (b = -1.80; P < 0.001). There was also evidence of a weak circadian component (acrophase ranging between 0651-0924 h) and an increase with time in the laboratory. Moreover, all these effects, except for the increase during sleep, differed significantly between individuals. CONCLUSION: In conclusion, testosterone increased during sleep and fell during waking, whereas circadian effects seemed marginal. Individual differences were pronounced.

Ort, förlag, år, upplaga, sidor
2005. Vol. 90, nr 8, s. 4530-5
Nyckelord [en]
Adult, Circadian Rhythm/*physiology, Humans, Male, Regression Analysis, Research Support; Non-U.S. Gov't, Sleep/*physiology, Testosterone/*blood, Wakefulness/*physiology
Identifikatorer
URN: urn:nbn:se:uu:diva-75447PubMedID: 15914523OAI: oai:DiVA.org:uu-75447DiVA, id: diva2:103358
Tillgänglig från: 2006-02-07 Skapad: 2006-02-07 Senast uppdaterad: 2011-01-11

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

PubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15914523&dopt=Citation

Personposter BETA

Holmbäck, Ulf

Sök vidare i DiVA

Av författaren/redaktören
Holmbäck, Ulf
Av organisationen
Institutionen för folkhälso- och vårdvetenskapInstitutionen för medicinska vetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetricpoäng

pubmed
urn-nbn
Totalt: 523 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf