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Recent advances in component resolved diagnosis in food allergy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
Kyoto Univ, Grad Sch Agr, Lab Food Qual Design & Dev, Kyoto, Japan..
Sagamihara Natl Hosp, Dept Allergy, Clin Res Ctr Allergol & Rheumatol, Sagamihara, Kanagawa, Japan..
Sagamihara Natl Hosp, Dept Allergy, Clin Res Ctr Allergol & Rheumatol, Sagamihara, Kanagawa, Japan..
2016 (English)In: Allergology International, ISSN 1323-8930, E-ISSN 1440-1592, Vol. 65, no 4, p. 378-387Article, review/survey (Refereed) Published
Abstract [en]

Due to the high prevalence of food allergic diseases globally there are increasing demands in clinical practice for managing IgE-mediated conditions. During the last decade, component resolved diagnostics has been introduced into the field of clinical allergology, providing information that cannot be obtained from extract-based tests. Component resolved data facilitate more precise diagnosis of allergic diseases and identify sensitizations attributable to cross-reactivity. Furthermore it assists risk assessment in clinical practice as sensitization to some allergenic molecules is related to persistence of clinical symptoms and systemic rather than local reactions. The information may also aid the clinician in prescription of oral immunotherapy (OIT) in patients with severe symptoms, and in giving advice on food allergen avoidance or on the need to perform food challenges. The use of allergen components is rapidly evolving and increases our possibility to treat food allergic patients with a more individual approach. Using molecular allergology, we can already now better diagnose, prognose and grade the food allergy. In summary, daily routine molecular allergy diagnostics offers a number of benefits that give us a higher diagnostic precision and allow for better management of the patient.

Place, publisher, year, edition, pages
2016. Vol. 65, no 4, p. 378-387
Keywords [en]
Allergen components, Component resolved diagnosis, Diagnosis, Food allergen, Molecular allergology
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-309479DOI: 10.1016/j.alit.2016.07.002ISI: 000385500400005PubMedID: 27543004OAI: oai:DiVA.org:uu-309479DiVA, id: diva2:1052099
Available from: 2016-12-05 Created: 2016-12-05 Last updated: 2018-01-13Bibliographically approved

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Borres, Magnus P.

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