uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Repetitive nerve stimulation often fails to detect abnormal decrement in acute severe generalized Myasthenia Gravis
Tartu Univ Hosp, Dept Neurol, Tartu, Estonia..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
2016 (English)In: Clinical Neurophysiology, ISSN 1388-2457, E-ISSN 1872-8952, Vol. 127, no 11, p. 3480-3484Article in journal (Refereed) Published
Abstract [en]

Objective: We assessed the diagnostic pattern of repetitive nerve stimulation (RNS) test and concentric electrode (CNE) jitter analysis between patients with generalized myasthenia gravis (GMG) with acute versus slow onset. Methods: All examinations that established the diagnosis of GMG at the department of Clinical Neurophysiology, Uppsala University Hospital, were retrospectively analyzed from January 2012 to December 2014. Patients were grouped according to disease duration at neurophysiological evaluation: acute onset (< 4 weeks) or slow onset (>= 4 weeks). Results: We identified 41 patients diagnosed with GMG. Of the nine patients with acute onset GMG (5 women) only one patient had abnormal decrement, whereas of the 32 patients with slow onset (13 women) 26 patients (84%) had abnormal decrement. CNE jitter was abnormal in all. AChR antibody status was comparable (78% versus 84%) whereas the MGFA class was higher in the acute onset group (range: 3A-5) compared to the slow onset group (range: 2A-3B). Conclusions: RNS test is frequently normal in cases of acute severe GMG, including myasthenic crisis. Performing CNE jitter analysis is therefore of crucial importance for a correct early diagnosis. Significance: MG patients with acute severe onset of bulbar or generalized fatigue often have normal findings on RNS test in proximal muscles. (C) 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
2016. Vol. 127, no 11, p. 3480-3484
Keywords [en]
Myasthenia gravis, Decrement, Repetitive nerve stimulation, CNE jitter
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-312985DOI: 10.1016/j.clinph.2016.09.012ISI: 000389510200010PubMedID: 27744133OAI: oai:DiVA.org:uu-312985DiVA, id: diva2:1069728
Available from: 2017-01-30 Created: 2017-01-16 Last updated: 2017-11-29Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Rostedt Punga, Anna

Search in DiVA

By author/editor
Rostedt Punga, Anna
By organisation
Clinical Neurophysiology
In the same journal
Clinical Neurophysiology
Neurology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 438 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf