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Taste disturbance after stapes surgery: an evaluation of frequency, severity, duration, and quality-of-life
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 37, nr 1, s. 39-43Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

 Conclusion: The incidence of taste disturbance after stapes surgery is high (61.9 %), whereas the majority (94.8 %) recovers within 1 year. More severe surgical nerve trauma caused more disturbance, implying that the nerve should be handled carefully during surgery.

 

Objectives: Patients operated on for otosclerosis seem more often to complain about post-operative taste disturbance than those operated on for chronic otitis media, although the chorda tympani nerve more seldom becomes maltreated in stapedotomy. These observations seem paradoxical. It is unclear to what extent a post-operative taste disturbance affects the quality-of-life. This study aims to shed light on the occurrence of post-operative taste disturbances, on possible prognostic factors, and to what extent post-operative taste disturbance impairs the quality-of-life.

 

Methods: One hundred and thirty-four adults undergoing primary stapedotomy were included. Questionnaires on taste disturbance and quality-of-life (SF-36) were answered before and after surgery, until 1 year post-operatively.

 

Results: Eighty-three (61.9%) study persons reported post-operative taste disturbance. Seven (5.2%) reported persisting disturbance at 1 year. Surgically more traumatized chorda tympani nerves correlated with more severe taste disturbance post-operatively than less traumatized.  Taste disturbance at 1 year post-operatively correlate with a decrease of the physical function domain in the SF-36.

sted, utgiver, år, opplag, sider
Taylor & Francis Group, 2017. Vol. 37, nr 1, s. 39-43
Emneord [en]
Chorda tympani nerve, otosclerosis, stapedotomy, taste, questionnaire, QoL, SF-36
HSV kategori
Forskningsprogram
Oto-rhino-laryngologi
Identifikatorer
URN: urn:nbn:se:uu:diva-315775DOI: 10.1080/00016489.2016.1217562ISI: 000390666600007OAI: oai:DiVA.org:uu-315775DiVA, id: diva2:1075785
Tilgjengelig fra: 2017-02-21 Laget: 2017-02-21 Sist oppdatert: 2018-09-13bibliografisk kontrollert
Inngår i avhandling
1. The Chorda Tympani Nerve: Role in Taste Impairment in Middle Ear Disease and after Ear Surgery
Åpne denne publikasjonen i ny fane eller vindu >>The Chorda Tympani Nerve: Role in Taste Impairment in Middle Ear Disease and after Ear Surgery
2017 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

The chorda tympani nerve, also known as the taste nerve, runs uncovered through the middle ear cavity, a localization that exposes the nerve to pathological processes and surgical trauma in the middle ear. People operated on for otosclerosis tend to complain more about postoperative taste disturbances than those operated on for chronic otitis media. It has been suggested that this difference may be explained by gradual deterioration of chorda tympani nerve function caused by chronic otitis media infection and that further impairment caused by surgery is less noticeable in these patients.

This thesis aimed to evaluate the function of the chorda tympani nerve, the effects of middle ear disease on taste and complications resulting from ear surgery for chronic otitis media or otosclerosis. This information will help to improve the ear surgeon’s ability to predict the prognosis of iatrogenic taste disturbances in patients with middle ear disease and after ear surgery.

Taste was assessed using electrogustometry and the filter paper disc method before and after surgery for chronic otitis media or otosclerosis. Patients also completed questionnaires about symptoms and quality of life. The status of the chorda tympani nerve upon surgical opening of the ear and grading of the trauma to the nerve during the surgery were recorded. The ultrastructure of the chorda tympani nerve from healthy ears and from ears with chronic otitis media was examined. Electrogustometry and the filter paper disc method were evaluated.

The results of electrogustometry and the filter paper disc method were highly reproducible, although their correlation was moderate. Patients with chronic otitis media, patients with a more traumatized nerve, female patients and younger patients were more likely to report postoperative taste disturbances. Most of the patients recovered their taste after 1 year. The quality of life study showed only minor changes after surgery. Electron microscopic observations of nerves from ears with chronic otitis media showed signs of structural degeneration, although signs of regeneration, such as sprouting were also observed. This results may explain the recovery of taste postoperatively and indicate that the nerve should be carefully handled during surgery.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2017. s. 54
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1306
Emneord
Chorda tympani nerve, ear surgery, taste, chronic suppurative otitis media, otosclerosis, electrogustometry, filter paper disc method, quality of life, transmission electron microscopy, degeneration, sprouting
HSV kategori
Forskningsprogram
Kirurgi
Identifikatorer
urn:nbn:se:uu:diva-316591 (URN)978-91-554-9837-5 (ISBN)
Disputas
2017-04-27, Vårdskolans Aula, Ing 21, Västmanlands sjukhus Västerås, Västerås, 13:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2017-04-05 Laget: 2017-03-07 Sist oppdatert: 2018-05-24

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