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Multifractal and mechanical analysis of amorphous solid dispersions.
2017 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, article id S0378-5173(17)30191-6Article in journal (Refereed) Epub ahead of print
Abstract [en]

The formulation of lipophilic and hydrophobic compounds is a challenge for the pharmaceutical industry and it requires the development of complex formulations. Our first aim was to investigate hot-melt extrudate microstructures by means of multifractal analysis using scanning electron microscopy imaging. Since the microstructure can affect solid dosage form performance such as mechanical properties, a second objective was to study the influence of the type of adsorbent and of the presence of an amorphous compound on extrudate hardness. β-Carotene (BC) was chosen as poorly water-soluble model compound. Formulations containing a polymer, a lipid and two different silica based inorganic carriers were produced by hot-melt extrusion. Based on scanning electron microscopy/energy dispersive X-ray spectroscopy, the obtained images were analyzed using multifractal formalism. The breaking force of the strands was assessed by a three point bending test. Multifractal analysis and three point bending results showed that the nature of interparticle interactions in the inorganic carrier as well as the presence of amorphous BC had an influence on the microstructure and thus on the mechanical performance. The use of multifractal analysis and the study of the mechanical properties were complementary to better characterize and understand complex formulations obtained by hot-melt extrusion.

Place, publisher, year, edition, pages
2017. article id S0378-5173(17)30191-6
Keywords [en]
Hot-melt extrusion, inorganic carrier, mechanical properties, multifractal, scanning electron microscopy, solid dispersion
National Category
Medicinal Chemistry Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-317924DOI: 10.1016/j.ijpharm.2017.03.014PubMedID: 28286079OAI: oai:DiVA.org:uu-317924DiVA, id: diva2:1083737
Available from: 2017-03-22 Created: 2017-03-22 Last updated: 2018-01-13

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