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Multifractal Characterization of Pharmaceutical Hot-Melt Extrudates.
2017 (English)In: Pharmaceutical research, ISSN 0724-8741, E-ISSN 1573-904X, Vol. 34, no 2, p. 321-332Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Multifractal geometry has become a powerful tool to describe complex structures in many fields. Our first aim was to combine imaging and multifractal analysis to better understand the microstructure of pharmaceutical extrudates. A second objective was to study erosion/dispersion behavior of the formulations because it would condition release of any drug.

METHODS: Different formulations containing a lipid, a polymer and different silica based inorganic carriers were produced by hot-melt extrusion at various screw speeds. Multifractal analysis was based on scanning electron microscopy/energy dispersive X-Ray spectroscopy images. This microstructural analysis was complemented with dynamic optical imaging of formulation erosion/dispersion behavior.

RESULTS: Multifractal analysis indicated that inorganic carrier type and concentration as well as the screw speed affected the microstructure of the extrudates. The aqueous erosion/dispersion study showed that only the type and concentration of inorganic carrier were important.

CONCLUSIONS: The use of microstructural and dispersion analysis appeared to be complementary to better characterize and understand complex formulations obtained by hot-melt extrusion.

Place, publisher, year, edition, pages
2017. Vol. 34, no 2, p. 321-332
Keywords [en]
dispersion, hot-melt extrusion, inorganic carrier, multifractal, scanning electron microscopy
National Category
Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-317925DOI: 10.1007/s11095-016-2064-4PubMedID: 27844187OAI: oai:DiVA.org:uu-317925DiVA, id: diva2:1083738
Available from: 2017-03-22 Created: 2017-03-22 Last updated: 2018-01-13

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