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Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemical endocrinology.ORCID iD: 0000-0002-9198-4193
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2017 (English)In: Biomarkers, ISSN 1354-750X, E-ISSN 1366-5804, Vol. 22, no 8, p. 775-781Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Circulating chromogranin B (CgB) levels are increased in situations characterized by systemic and myocardial stress, but whether CgB provides prognostic information in patients with acute respiratory failure (ARF) is unknown.

METHODS: We included 584 patients with ARF, defined as ventilatory support >6 h, and with blood samples available on Intensive Care Unit (ICU) admission and day 3 (n = 479). CgB levels were measured by radioimmunoassay and follow-up was 90 days.

RESULTS: One-hundred-sixty-nine patients (29%) died during follow-up. Admission CgB levels separated non-survivors from survivors: median 1234 (Q1-3 989-1742) vs. 917 (753-1224) pmol/L, respectively, p < 0.001. CgB levels on ICU admission (logarithmically transformed) were associated with time to death after adjustment for established risk indices available on ICU admission, including N-terminal pro-B-type natriuretic levels: HR 2.62 (95%C.I. 1.82-3.77), p < 0.001. Admission CgB levels also improved prognostication on top of SOFA and SAPS II scores as assessed by Cox regression analyses and the category-free net reclassification index. The area under the curve (AUC) for admission CgB levels to separate survivors and non-survivors was 0.72 (95%CI 0.67-0.76), while the AUC on day 3 was 0.60 (0.54-0.66).

CONCLUSIONS: CgB levels measured on ICU admission provided additional prognostic information to established risk indices in ARF patients.

Place, publisher, year, edition, pages
2017. Vol. 22, no 8, p. 775-781
Keywords [en]
Chromogranin B, acute respiratory failure, biomarker, prognosis
National Category
Cardiac and Cardiovascular Systems
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URN: urn:nbn:se:uu:diva-318356DOI: 10.1080/1354750X.2016.1269200ISI: 000416064700010PubMedID: 28049363OAI: oai:DiVA.org:uu-318356DiVA, id: diva2:1084379
Available from: 2017-03-24 Created: 2017-03-24 Last updated: 2018-02-26Bibliographically approved

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