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From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.ORCID-id: 0000-0001-7376-7331
Vise andre og tillknytning
2017 (engelsk)Inngår i: Endocrine-Related Cancer, ISSN 1351-0088, E-ISSN 1479-6821, Vol. 24, nr 4, s. C5-C8Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.

sted, utgiver, år, opplag, sider
2017. Vol. 24, nr 4, s. C5-C8
Emneord [en]
nomenclature, pituitary tumors
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-318372DOI: 10.1530/ERC-17-0004ISI: 000395905600001PubMedID: 28264912OAI: oai:DiVA.org:uu-318372DiVA, id: diva2:1084391
Tilgjengelig fra: 2017-03-24 Laget: 2017-03-24 Sist oppdatert: 2017-11-29bibliografisk kontrollert

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