uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Expression of Semaphorins, Neuropilins, VEGF, and Tenascins in Rat and Human Primary Sensory Neurons after a Dorsal Root Injury
Karolinska Inst, Dept Neurosci, Stockholm, Sweden.;Helsa Foretagshalsovard Ostermalm, Stockholm, Sweden..
Karolinska Inst, Dept Neurosci, Stockholm, Sweden..
Karolinska Inst, Dept Neurosci, Stockholm, Sweden.;UCL, Hammersmith Hosp, London WC1E 6BT, England.;Imperial Coll, London, England.;Soder Sjukhuset, Dept Hand Surg, Stockholm, Sweden.;Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden..
Karolinska Inst, Dept Neurosci, Stockholm, Sweden.;Soder Sjukhuset, Dept Hand Surg, Stockholm, Sweden.;Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden..
Vise andre og tillknytning
2017 (engelsk)Inngår i: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 8, artikkel-id 49Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Dorsal root injury is a situation not expected to be followed by a strong regenerative growth, or growth of the injured axon into the central nervous system of the spinal cord, if the central axon of the dorsal root is injured but of strong regeneration if subjected to injury to the peripherally projecting axons. The clinical consequence of axonal injury is loss of sensation and may also lead to neuropathic pain. In this study, we have used in situ hybridization to examine the distribution of mRNAs for the neural guidance molecules semaphorin 3A (SEMA3A), semaphorin 3F (SEMA3F), and semaphorin 4F (SEMA4F), their receptors neuropilin 1 (NP1) and neuropilin 2 (NP2) but also for the neuropilin ligand vascular endothelial growth factor (VEGF) and Tenascin J1, an extracellular matrix molecule involved in axonal guidance, in rat dorsal root ganglia (DRG) after a unilateral dorsal rhizotomy (DRT) or sciatic nerve transcetion (SNT). The studied survival times were 1-365 days. The different forms of mRNAs were unevenly distributed between the different size classes of sensory nerve cells. The results show that mRNA for SEMA3A was diminished after trauma to the sensory nerve roots in rats. The SEMA3A receptor NP1, and SEMA3F receptor NP2, was significantly upregulated in the DRG neurons after DRT and SNT. SEMA4F was upregulated after a SNT. The expression of mRNA for VEGF in DRG neurons after DRT showed a significant upregulation that was high even a year after the injuries. These data suggest a role for the semaphorins, neuropilins, VEGF, and J1 in the reactions after dorsal root lesions.

sted, utgiver, år, opplag, sider
2017. Vol. 8, artikkel-id 49
Emneord [en]
rhizothomy, DRG, regeneration, semaphorins, neuropilins, VEGF
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-317941DOI: 10.3389/fneur.2017.00049ISI: 000394339300001PubMedID: 28270793OAI: oai:DiVA.org:uu-317941DiVA, id: diva2:1086344
Tilgjengelig fra: 2017-04-01 Laget: 2017-04-01 Sist oppdatert: 2018-01-13bibliografisk kontrollert

Open Access i DiVA

fulltext(5271 kB)134 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 5271 kBChecksum SHA-512
ec5dd25a3e209b63f4c1fabf941cea65a1f81d12600703ffcdf645f61592497f9085626159dd3c5da2cb04aeb7b7e3aaa5223c0035bfd68b14d987acbf39d03a
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Sköld, Mattias K.

Søk i DiVA

Av forfatter/redaktør
Sköld, Mattias K.
Av organisasjonen
I samme tidsskrift
Frontiers in Neurology

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 134 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 496 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf