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Within-session effect of repeated stress exposure on extinction circuitry function in social anxiety disorder
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Obstetrik & gynekologi.
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
2017 (engelsk)Inngår i: Psychiatry Research: Neuroimaging, ISSN 0925-4927, E-ISSN 1872-7506, Vol. 261, s. 85-90Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Anxiety reduction following repeated exposure to stressful experiences is generally held to depend on neural processes involved in extinction of conditioned fear. We predicted that repeated exposure to stressful experiences would change activity throughout the circuitry serving extinction, including ventromedial prefrontal cortex (vmPFC), the hippocampus and the amygdala. To test this prediction, 36 participants diagnosed with SAD performed two successive speeches in front of an observing audience while regional cerebral blood flow (rCBF) was recorded using positron emission tomography. To control for non-anxiolytic effects of repeated exposure, rCBF was also measured during repeated presentations of neutral and angry facial expressions. Results showed that anxiety ratings and heart rate decreased from the first to the second speech, indicating an anxiolytic effect of repeated exposure. Exposure attenuated rCBF in the amygdala whereas no change in rCBF was observed in the vmPFC or hippocampus. The rCBF-reductions in the amygdala were greater following repetition of the speech task than repetition of face exposure indicating that they were specific to anxiety attenuation and not due to a reduced novelty. Our findings suggest that amygdala-related attenuation processes are key to understanding the working mechanisms of exposure therapy.

sted, utgiver, år, opplag, sider
ELSEVIER IRELAND LTD , 2017. Vol. 261, s. 85-90
Emneord [en]
Extinction, Social phobia, Cognitive behavior therapy, Amygdala, Hippocampus, VmPFC
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Identifikatorer
URN: urn:nbn:se:uu:diva-320032DOI: 10.1016/j.pscychresns.2017.01.009ISI: 000395958900012PubMedID: 28167379OAI: oai:DiVA.org:uu-320032DiVA, id: diva2:1088575
Forskningsfinansiär
Swedish Research CouncilThe Swedish Brain FoundationTilgjengelig fra: 2017-04-13 Laget: 2017-04-13 Sist oppdatert: 2017-11-29bibliografisk kontrollert

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Åhs, FredrikGingnell, MalinFurmark, TomasFredrikson, Mats

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