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Development of new levodopa treatment strategies in Parkinson’s disease – from bedside to bench to bedside
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.ORCID iD: 0000-0001-9776-7715
2017 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 122, no 2, p. 71-77Article, review/survey (Refereed) Published
Abstract [en]

This review will illustrate the process of moving from an idea through preclinical research and Galenic developments into clinical investigations and finally to approval by regulatory agencies within the European Union. The two new treatment strategies described, levodopa/carbidopa intestinal gel and levodopa/carbidopa microtablets, for advanced Parkinson's disease, have been developed in collaborative research within departments at Uppsala University. With this historical approach, reference priority is given to reports considered to be of special importance for this more than two decades long process from bedside to bench to bedside'.

Place, publisher, year, edition, pages
2017. Vol. 122, no 2, p. 71-77
Keywords [en]
Carbidopa; drug development; intestinal gel; levodopa; microtablets; Parkinson's disease
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-320484DOI: 10.1080/03009734.207.1285374ISI: 000401756500001PubMedID: 28276779OAI: oai:DiVA.org:uu-320484DiVA, id: diva2:1089663
Available from: 2017-04-20 Created: 2017-04-20 Last updated: 2017-10-17Bibliographically approved

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Aquilonius, Sten-MagnusNyholm, Dag

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