Sodium supply influences plasma sodium concentration and the risks of hyper- and hyponatremia in extremely preterm infantsVise andre og tillknytning
2017 (engelsk)Inngår i: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 81, nr 3, s. 455-460Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
BACKGROUND: Hyper- and hyponatremia occur frequently in extremely preterm infants. Our purpose was to investigate plasma sodium (P-Na) concentrations, the incidence of hyper and hyponatremia, and the impact of possible predisposing factors in extremely preterm infants. METHODS: In this observational study, we analyzed data from the EXtremely PREterm (< 27wk.) infants in Sweden Study (EXPRESS, n = 707). Detailed nutritional, laboratory, and weight data were collected retrospectively from patient records. RESULTS: Mean +/- SD P-Na increased from 135.5 +/- 3.0 at birth to 144.3 +/- 6.1 mmol/l at a postnatal age of 3 d and decreased thereafter. Fifty percent of infants had hypernatremia (P-Na > 145 mmol/l) during the first week of life while 79% displayed hyponatremia (P-Na < 135 mmol/l) during week 2. Initially, the main sodium sources were blood products and saline injections/infusions, gradually shifting to parenteral and enteral nutrition towards the end of the first week. The major deter, minant of P-Na and the risks of hyper- and hyponatremia was sodium supply. Fluid volume provision was associated with postnatal weight change but not with P-Na. CONCLUSION: The supply of sodium, rather than fluid volume, is the major factor determining P-Na concentrations and the risks of hyper- and hyponatremia.
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NATURE PUBLISHING GROUP , 2017. Vol. 81, nr 3, s. 455-460
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URN: urn:nbn:se:uu:diva-320874DOI: 10.1038/pr.2016.264ISI: 000396297000016PubMedID: 27935901OAI: oai:DiVA.org:uu-320874DiVA, id: diva2:1091158
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