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Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects
Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England.;Diamond Light Source, Harwell Sci & Innovat Campus,Fermi Ave, Didcot OX11 0QX, Oxon, England..
Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England.;Diamond Light Source, Harwell Sci & Innovat Campus,Fermi Ave, Didcot OX11 0QX, Oxon, England..
Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England..
Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England..
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2017 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 23, no 21, p. 4981-4985Article in journal (Refereed) Published
Abstract [en]

X-ray crystal structures of three -[Ru(L)(2)dppz](2+) complexes (dppz=dipyridophenazine; L=1,10-phenanthroline (phen), 2,2-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5-CG-3 step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH2 group, in contrast to symmetrical intercalation previously observed at 5-TA-3 sites. This result suggests that canted intercalation is preferred at 5-CG-3 sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5-CG-3 step could give rise to a longer luminescence lifetime than canted intercalation.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2017. Vol. 23, no 21, p. 4981-4985
Keywords [en]
DNA, DNA structures, nucleic acids, structural biology
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-323657DOI: 10.1002/chem.201605508ISI: 000399327400005PubMedID: 28105682OAI: oai:DiVA.org:uu-323657DiVA, id: diva2:1115072
Available from: 2017-06-26 Created: 2017-06-26 Last updated: 2017-06-26Bibliographically approved

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Andersson, Johanna

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