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Improved positioning and detectability of microparticles in droplet microfluidics using two-dimensional acoustophoresis
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. (EMBLA)ORCID iD: 0000-0002-7023-4772
Lund University, Lund, Sweden. (EMBLA)ORCID iD: 0000-0001-7980-376X
Tech Univ Denmark, Lyngby, Denmark.ORCID iD: 0000-0001-5827-2939
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. Uppsala University, Science for Life Laboratory, SciLifeLab. Lund University, Lund, Sweden. (EMBLA)ORCID iD: 0000-0002-1264-1337
2017 (English)In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 27, no 8, article id 084002Article in journal (Refereed) Published
Abstract [en]

We have fabricated a silicon-glass two-phase droplet microfluidic system capable of generating sub 100 µm-sized,   =  (74  ±  2) µm, spherical droplets at rates of up to hundreds of hertz. By implementing a two-dimensional (2D) acoustophoresis particle-positioning method, we show a fourfold improvement in both vertical and lateral particle positioning inside the droplets compared to unactuated operation. The efficiency of the system has been optimized by incorporating aluminum matching layers in the transducer design permitting biocompatible operational temperatures (<37 °C). Furthermore, by using acoustic actuation, (99.8  ±  0.4)% of all encapsulated microparticles can be detected compared to only (79.0  ±  5.1)% for unactuated operation. In our experiments we observed a strong ordering of the microparticles in distinct patterns within the droplet when using 2D acoustophoresis; to explain the origin of these patterns we simulated numerically the fluid flow inside the droplets and compared with the experimental findings.

Place, publisher, year, edition, pages
2017. Vol. 27, no 8, article id 084002
National Category
Nano Technology
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
URN: urn:nbn:se:uu:diva-327204DOI: 10.1088/1361-6439/aa7967ISI: 000415698300001OAI: oai:DiVA.org:uu-327204DiVA, id: diva2:1129793
Funder
The Crafoord Foundation, 20130569Carl Tryggers foundation , CTS14478Swedish Research Council, 612-2013-5920Available from: 2017-08-07 Created: 2017-08-07 Last updated: 2018-02-26Bibliographically approved

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Ohlin, MathiasTenje, Maria

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