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Targeting lipodisks enable selective delivery of anticancer peptides to tumor cells
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi. (Edwards grupp)ORCID-id: 0000-0003-0674-2219
2017 (engelsk)Inngår i: Nanomedicine: Nanotechnology, Biology and Medicine, ISSN 1549-9634, E-ISSN 1549-9642, Vol. 13, nr 7, s. 2325-2328Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Issues concerning non-specificity, degradation and hemolysis severely hamper the development of membranolytic amphiphilic peptides into safe and efficient anticancer agents. To increase the therapeutic potential, we have previously developed a strategy based on formulation of the peptides in biocompatible nanosized lipodisks. Studies using melittin as model peptide show that the proteolytic degradation and hemolytic effect of the peptide are substantially reduced upon loading in lipodisks. Here, we explored the possibilities to increase the specificity and boost the cytotoxicity of melittin to tumor cells by use of targeting lipodisk. We demonstrate that small (~20 nm) EGF-targeted lipodisks can be produced and loaded with substantial amounts of peptide (lipid/peptide molar ratio >7) by means of a simple and straightforward preparation protocol. In vitro cell studies confirm specific binding of the peptide-loaded disks to tumor cells and suggest that cellular internalization of the disks results in a significantly improved cell-killing effect.

sted, utgiver, år, opplag, sider
2017. Vol. 13, nr 7, s. 2325-2328
Emneord [en]
EGFR, Melittin, Nanocarrier, PEG-stabilized lipid disk, Selective targeting
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-327972DOI: 10.1016/j.nano.2017.06.020ISI: 000411954200023PubMedID: 28712916OAI: oai:DiVA.org:uu-327972DiVA, id: diva2:1131470
Tilgjengelig fra: 2017-08-14 Laget: 2017-08-14 Sist oppdatert: 2018-01-31

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