uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The role of Lawesson's reagent in the total synthesis of macrocyclic natural products
Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
Show others and affiliations
2017 (English)In: Phosphorus Sulfur and Silicon and the Related Elements, ISSN 1042-6507, E-ISSN 1563-5325, Vol. 192, no 5, p. 490-502Article, review/survey (Refereed) Published
Abstract [en]

This review, including 111 references, describes the applications of Lawesson's reagent (LR) [2,4-bis(p-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-dithione] for the total synthesis of macrocyclic natural products. LR is a versatile reagent and shows excellent regioselectivity, chemoselectivity, and offers the products in high yield. The thionation of carbonyl moieties present in macrocyclic natural products, and cyclization to construct key heterocyclic fragments is described. Moreover, this review highlights the medicinal significance of the natural products. [GRAPHICS] .

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2017. Vol. 192, no 5, p. 490-502
Keywords [en]
Lawesson's reagent, macrocycles, total synthesis, thionation, medicinal value
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-328849DOI: 10.1080/10426507.2016.1259236ISI: 000399932500003OAI: oai:DiVA.org:uu-328849DiVA, id: diva2:1137875
Available from: 2017-09-01 Created: 2017-09-01 Last updated: 2017-09-01Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text
By organisation
Department of Medicinal Chemistry
In the same journal
Phosphorus Sulfur and Silicon and the Related Elements
Organic Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 107 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf