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Heavy metal concentrations in female wild mink (Neovison vison) in Sweden: Sources of variation and associations with internal organ weights
Swedish Univ Agr Sci, Div Reprod, Dept Clin Sci, Uppsala, Sweden..
Swedish Univ Agr Sci, Div Reprod, Dept Clin Sci, Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
Swedish Univ Agr Sci, Div Reprod, Dept Clin Sci, Uppsala, Sweden..
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2017 (English)In: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 36, no 8, p. 2030-2035Article in journal (Refereed) Published
Abstract [en]

The American mink is an invasive species in Sweden, and it is legally hunted all year. Therefore, the mink is well suited as a sentinel species for environmental monitoring. In the present study female mink (n = 91) from 6 different areas in Sweden were analyzed for the concentrations of silver, cadmium, mercury and lead in liver tissue using inductively coupled plasma mass spectrometry. The wet concentrations in liver tissue were 42.6 +/- 52.7 ng/g for silver, 99.5 +/- 100 ng/g for cadmium, 652 +/- 537 ng/g formercury, and 196 +/- 401 ng/g for lead (expressed as mean + standard deviation). There were associations between the sample area and the concentrations of silver, lead, and mercury. The concentrations of lead and cadmium varied with season of capture and lead, cadmium, and mercury were positively associated with increasing age. Relative liver weight was positively associated with concentrations of mercury and negatively associated with lead and cadmium. Relative kidney weight was negatively associated with lead concentrations. In summary, it is of importance to take age and season of capture into account when assessing levels of heavy metals in wild mink. Also, liver and kidneys seem to be potential targets for heavy metal toxicity in wild female mink in Sweden.

Place, publisher, year, edition, pages
2017. Vol. 36, no 8, p. 2030-2035
Keywords [en]
Wildlife toxicology, Metal accumulation, Metal toxicity, Mink, Liver, Kidney
National Category
Environmental Sciences Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-333514DOI: 10.1002/etc.3717ISI: 000406398400011OAI: oai:DiVA.org:uu-333514DiVA, id: diva2:1158384
Available from: 2017-11-20 Created: 2017-11-20 Last updated: 2019-10-10Bibliographically approved
In thesis
1. Method development for the analysis of complex samples with inductively coupled plasma mass spectrometry
Open this publication in new window or tab >>Method development for the analysis of complex samples with inductively coupled plasma mass spectrometry
2019 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In this thesis the development of methods for handling the problems associated with analyzing trace elements in complex matrixes using inductively coupled plasma mass spectrometry is presented. Trace elements such as Cu, Fe, Se, and Zn, to name a few, do play important roles in different organisms. Therefore it can be of importance to study trace elements in different samples of biological origin. As trace elements are low in abundance, sensitive instrumental techniques such as inductively coupled plasma mass spectrometry (ICP-MS) are required for accurate determination. Due to the complexity of samples with biological origin, careful method development, both regarding the sample preparation and instrumental analysis has to be performed to minimize negative effects on the instrument signal and introduction of interferences.

For example the metal contents of mink livers were analyzed, after bomb digestion to investigate if the metal concentration could be linked to changes in the organ morphology as well as the minks’ environment. Morphological changes and capture locations could be linked to the metals investigated. The investigation of the elemental composition of cerebrospinal fluid from chronic pain patients using spinal cord stimulation electrode treatment on the other hand required less harsh sample treatment. No correlation between the spinal cord stimulation and element concentration could be found, but differences between patients and the control group were presented hinting that chronic pain intrinsically could affect the cerebrospinal fluid metal concentration. Another bodily fluid of interest is saliva and the use of paperpoint sticks as a sampling technique for Ti in saliva was investigated. As Ti is interfered by several components expected to be found in saliva, the use of reaction or collision gas was also investigated to reduce the effects of interferences. Simple leaching of the paperpoint sticks together with complexing the Ti with NH3 as reaction gas was shown to be optimal. Finally, how the selection of internal standard would be affected by the use of reaction and collision gases was also investigated. With collision gas most internal standards worked fine, while for reaction gas internal standard selection was harder. For elements with high ionization energy such as As, Se and Zn the choice of internal standard was very dependent on matrix. While ICP-MS suffers from problems when analyzing samples with complex matrixes many of them can be minimized by proper method development as shown in this thesis.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2019. p. 52
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1865
Keywords
ICP-MS, trace elements, complex matrix.
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:uu:diva-394936 (URN)978-91-513-0772-5 (ISBN)
Public defence
2019-11-29, B41, BMC, Husargatan 3, Uppsala, 13:15 (English)
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Supervisors
Available from: 2019-11-08 Created: 2019-10-10 Last updated: 2019-11-08

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Korvela, MarcusBergquist, Jonas

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