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A pathology atlas of the human cancer transcriptome
KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.;Danish Tech Univ, Ctr Biosustainabil, Copenhagen, Denmark.;Royal Inst Technol, AlbaNova Univ Ctr, KTH, Sch Biotechnol, Stockholm, Sweden..
KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden..
KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden..
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk och experimentell patologi. KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
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2017 (engelsk)Inngår i: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 357, nr 6352, artikkel-id eaan2507Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.

sted, utgiver, år, opplag, sider
AMER ASSOC ADVANCEMENT SCIENCE , 2017. Vol. 357, nr 6352, artikkel-id eaan2507
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Forskningsprogram
Patologi
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URN: urn:nbn:se:uu:diva-334302DOI: 10.1126/science.aan2507ISI: 000407793600028OAI: oai:DiVA.org:uu-334302DiVA, id: diva2:1159296
Forskningsfinansiär
Swedish Cancer SocietyScience for Life Laboratory - a national resource center for high-throughput molecular bioscienceKnut and Alice Wallenberg FoundationSwedish Research CouncilTilgjengelig fra: 2017-11-22 Laget: 2017-11-22 Sist oppdatert: 2019-03-29bibliografisk kontrollert

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Sjöstedt, EvelinaMattsson, Johanna Sofia MargaretaGlimelius, BengtSjöblom, TobiasEdqvist, Per-Henrik DDjureinovic, DijanaMicke, PatrickLindskog, CeciliaPonten, Fredrik

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Sjöstedt, EvelinaMattsson, Johanna Sofia MargaretaGlimelius, BengtSjöblom, TobiasEdqvist, Per-Henrik DDjureinovic, DijanaMicke, PatrickLindskog, CeciliaPonten, Fredrik
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