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Targeted proteomic analysis of habitual coffee consumption.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
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2018 (Engelska)Ingår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 283, nr 2, s. 200-211Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Coffee drinking has been implicated in mortality and a variety of diseases but potential mechanisms underlying these associations are unclear. Large-scale systems epidemiological approaches may offer novel insights to mechanisms underlying associations of coffee with health.

OBJECTIVE: We performed an analysis of known and novel protein markers linked to cardiovascular disease and their association with habitual coffee intake in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS, n = 816) and followed up top proteins in the Uppsala Longitudinal Study of Adult Men (ULSAM, n = 635) and EpiHealth (n = 2418).

METHODS: In PIVUS and ULSAM, coffee intake was measured by 7-day dietary records whilst a computer-based food frequency questionnaire was used in EpiHealth. Levels of up to 80 proteins were assessed in plasma by a proximity extension assay.

RESULTS: Four protein-coffee associations adjusted for age, sex, smoking and BMI, met statistical significance in PIVUS (FDR < 5%, P < 2.31 × 10(-3) ): leptin (LEP), chitinase-3-like protein 1 (CHI3L), tumour necrosis factor (TNF) receptor 6 and TNF-related apoptosis-inducing ligand. The inverse association between coffee intake and LEP replicated in ULSAM (β, -0.042 SD per cup of coffee, P = 0.028) and EpiHealth (β, -0.025 SD per time of coffee, P = 0.004). The negative coffee-CHI3L association replicated in EpiHealth (β, -0.07, P = 1.15 × 10(-7) ), but not in ULSAM (β, -0.034, P = 0.16).

CONCLUSIONS: The current study supports an inverse association between coffee intake and plasma LEP and CHI3L1 levels. The coffee-CHI3L1 association is novel and warrants further investigation given links between CHI3L1 and health conditions that are also potentially influenced by coffee.

Ort, förlag, år, upplaga, sidor
2018. Vol. 283, nr 2, s. 200-211
Nyckelord [en]
biomarkers, coffee, epidemiology, population, proteomics
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
URN: urn:nbn:se:uu:diva-334452DOI: 10.1111/joim.12703ISI: 000425830100008PubMedID: 29044854OAI: oai:DiVA.org:uu-334452DiVA, id: diva2:1159642
Tillgänglig från: 2017-11-23 Skapad: 2017-11-23 Senast uppdaterad: 2018-05-07Bibliografiskt granskad

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Gustafsson, StefanSundström, JohanMichaëlsson, KarlLind, LarsIngelsson, Erik

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Gustafsson, StefanSundström, JohanMichaëlsson, KarlLind, LarsIngelsson, Erik
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Molekylär epidemiologiScience for Life Laboratory, SciLifeLabKardiovaskulär epidemiologiUppsala kliniska forskningscentrum (UCR)Ortopedi
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Journal of Internal Medicine
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

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